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. 2018 Oct 18;8:15402. doi: 10.1038/s41598-018-33865-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of Akt or MMP-1 blocks invasion of HPV16-immortalized cells. (a) HPV16-immortalized TZ cells were seeded on collagen rafts with cervical stromal cells and then treated for 10 days with the Akt inhibitor SC 66 (2 µg/ml) or the MMP inhibitor GM6001 (10 μM) in DMSO. Untreated cultures received only DMSO. Dotted lines indicate position of basement membranes. (b) Mean invasion index ± standard error of three organotypic cultures. Bars show values that are statistically different (3 asterisks = p < 0.001).