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. 2018 Oct 12;9:1297. doi: 10.3389/fphys.2018.01297

FIGURE 4.

FIGURE 4

Of 11 miR-221 mRNA targets that have been experimentally verified in any of the four hyperlipidemia-related disease backgrounds, PTEN and ETS1 mRNAs are negatively regulated in three out of four hyperlipidemia-related diseases. (A) From an original list of 82 miR-221 mRNA targets, we identified via PubMed the targets that were tested in any of the four diseases. We found 11 mRNA targets met this criterion. (B) Moreover, few mRNA targets were shared between diseases; and Venn diagram shows that PTEN and ETS1 mRNAs are negatively regulated by miR-221 in three out of four hyperlipidemia-related diseases. NAFLD, non-alcoholic fatty liver disease; T2DM/IR, type 2 diabetes mellitus/insulin resistance.