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. 2018 Oct 12;9:1297. doi: 10.3389/fphys.2018.01297

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Copyright © 2018 Johnson, Drummer, Virtue, Gao, Wu, Hernandez, Singh, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top pathways in hyperlipidemia-related diseases, MHO, and cancer show multiple shared pathways. The top 25 (Atherosclerosis), 23 (Cancer), 15 (MHO), 12 (NAFLD), 25 (Obesity), 19 (T2DM) pathways were chosen. A 6-way Venn diagram was then constructed, which show that (A) various pathways are shared between hyperlipidemia-related diseases, MHO, and cancer. (B) Atherosclerosis Signaling and Pathogenesis of Multiple Sclerosis pathways link three disease conditions and MHO together. MHO, metabolically healthy obesity.