Table 3.

Main candidate gene associations for cHOMA-B and log HOMA-IR.

rsID	Chr	Position	Alleles	MAF	Gene	Location	cHOMA-B		HOMA-IR		Diabetes
							Beta	P-value	Beta	P-value	Beta	P-value
rs4135273	3	12414329	G/A	0.01	PPARG	intron	−0.01	0.01	−0.21	0.05	−0.04	0.62
rs16860216	3	186971576	G/A	0.13	IGF2BP2	intergenic	0.13	0.02	−0.07	0.03	−0.03	0.57
rs3731201	9	21978896	A/G	0.04	CDKN2A	intron	−0.01	0.09	−0.02	0.39	−0.01	0.76
rs3218018	9	21988139	A/C	0.03	CDKN2B	intergenic	−0.06	0.18	−0.08	0.24	−0.05	0.72
rs4639863	10	114844373	G/A	0.37	TCF7L2	intergenic	0.23	0.01	0.08	0.04	−0.01	0.75
rs163170	11	2778003	G/A	0.50	KCNQ1	intron	0.04	6.27 × 10−6	−0.11	2.16 × 10−4	−0.01	0.92
rs35379941	12	119909772	T/A	0.11	HNF1A	intron	−0.01	0.35	0.06	0.17	0.02	0.41

Gene base position based on NCBI36/hg18 build. Chr, chromosome; cHOMA-B, corrected homeostatic model assessment – B cell function; MAF, minor allele frequency. P < 0.05 for significant replication.