Figure 1.

The natural history of endometriosis and cancer driver mutations (adapted from Ref. 401). This diagram sketches, in broad strokes, the progression of endometriotic lesions, which interact with various players in their microenvironment, through epithelial‐mesenchymal transition (EMT), fibroblast‐to‐myofibroblast transdifferentiation (FMT), and smooth muscle metaplasia (SMM), leading ultimately to fibrosis. In addition, it depicts cancer driver mutations are likely induced by the pressure of fibrogenesis of endometriosis. EMT, epithelial‐mesenchymal transition; FMT, fibroblast‐to‐myofibroblast transdifferentiation; SMM, smooth muscle metaplasia