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. 2018 Oct 12;8:425. doi: 10.3389/fonc.2018.00425

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Copyright © 2018 Leung, Askarian-Amiri, Singleton, Ferraro-Peyret, Joseph, Finlay, Broom, Kakadia, Bohlander, Marshall and Baguley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signaling pathway usage and growth inhibitory concentrations for NZBR cell lines exposed to different drugs. (A) Signaling pathway usage as measured by phosphorylation of AKT, p70S6K, rpS6 and ERK. Immunoblots with antibodies specific for phosphorylated proteins and their respective total protein are indicated. Tubulin is the loading control. IC50 values for (B) everolimus, and (C) NVP-BEZ235, shown as the mean ± standard error of triplicate experiments. Cell lines are identified as estrogen receptor (ER) positive, HER2 positive and triple negative (TN) (orange, here and below).