Table 2.

Nine genes with mutations in the New Zealand breast cancer cell lines.

Cell line	Gene	Mutation		Impact	Number of times reported
		Nucleotide	Amino acids
NZBR2	BRCA2	c.6070C > A,	Q2024K	High	25
	AKT1	c.1234G > A	V412M	High	12
NZBR3	NF1	c.932G > A	G311E	Moderate	15
	EVI2B	c.881C > G	S294*	High	ND
	LRP1B	c.10567G > C	A3523P	Moderate	4
		c.3578G > C	R1193T	Moderate
NZBR4	MRE11A	c.1394T > G	V465G	Moderate	1
	PMS2	c.977C > T	S326F	Moderate	1
	MLH1	c.1460G >C	R487P	Moderate	1
		c.1852A > G	K618E	Moderate
		c.1853A > C	K618T	Moderate
		c.977C > T	S326F	Moderate
	ATM	c.2672C > G	S891*	High	21
	BRCA2	c.9976A > T	K3326*	High	25

Among the mutations found in NZBR lines, only the BRCA2 c.9976A > T mutation has previously been reported in the breast carcinoma dataset from cBioPortal using The Cancer Genome Atlas (TCGA) Breast Invasive Carcinoma project (n = 825 cases) from Nature 2012 (27).

^*, stop codon.