Table 3.
Mutated genes of New Zealand breast cancer cell lines found in other breast cancer cell lines.
| Mutation | Cell line | Protein change | Mutation type |
|---|---|---|---|
| AKT1 | MDA-MB-361 | D3N | Missense |
| ATM | HCC1500 | W2638* | Nonsense |
| BT474 | E2468K | Missense | |
| EVSAT | L1472F | Missense | |
| HCC1569 | L1824F | Missense | |
| MDA-MB-453 | E1856Q | Missense | |
| BRCA2 | HCC1395 | E1593* | Nonsense |
| HCC1569 | V1862* | Frame Shift Deletion | |
| HCC1599 | K1517Ifs*23 | Frame Shift Deletion | |
| BT474 | S3094* | Nonsense Mutation | |
| BT20 | T3357R | Missense | |
| HCC1569 | N1100T | Missense | |
| MDA-MB-361 | N1657S | Missense | |
| ZR7530 | M2322I | Missense | |
| EVI2B | ND | ||
| LRP1B | ND | ||
| MLH1 | BT20 | E578G | Missense |
| HCC1428 | D132H | Missense | |
| MRE11A | HCC2218 | H302Y | Missense |
| MDA-MB-134VI | R380C | Missense | |
| NF1 | BT483 | R1204W | Missense |
| HCC202 | X465_splice | Splice Site | |
| MDA-MB-231 | T467Hfs*3 | Frame Shift Insertion | |
| EFM192A | Q347H | Missense | |
| MDA-MB-468 | Q1033R | Missense | |
| UACC893 | Q1033R | Missense | |
| UACC893 | F1037C | Missense | |
| HS578T | G2745R | Missense | |
| PMS2 | ND |
Cell lines with mutated genes from cBioPortal (www.cbioportal.org) using Cancer Cell Line Encyclopedia (Novartis/Broad, Nature 2012) breast cancer cell lines (n = 56). ND, no data;
*
, stop codon.