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. 2018 Oct 18;27(9):1624–1635. doi: 10.1002/pro.3459

Figure 4.

Figure 4

Global Quality Analysis of IκBε homology models suggests Bcl‐3 and IκBβ templates generate the most accurate structures. The SWISS model platform generates a Global Model Quality Estimate (GMQE) score which combines properties from the target‐template alignment and the template search method and is expressed as a number between 0 and 1 with higher scores indicating higher quality. The GMQE score for each model is shown above. The platform also generates specific Z‐scores for four structural descriptors: All Atom, CBeta, Solvation, and Torsion. The QMEAN4 scoring function is a linear combination using statistical potentials of these four components. The Z‐scores shown to the right relate the quality of the structural descriptors to those of high‐resolution X‐ray structures of similar size. The QMEAN4 Z‐score provides a “degree of nativeness” of each model. (A) Scores for the Bcl‐3 template model. (B) Scores for the IκBβ template model. (C) Scores for the IκBα template model. Although the IκBβ template model has a GMQE score marginally higher than that of the Bcl‐3 template model, the Bcl‐3 template model outperforms it in individual Z‐scores shown to the right. This global quality analysis eliminates the IκBα template model as the QMEAN4 lower limit for a quality model is −4.0 and the IκBα template model was scored as −5.71.