Table 1.
The pharmacokinetic parameters of danofloxacin following multiple doses in a piglet tissue-cage infection model.
| Dosages (mg/kg) | AUC24h (μg⋅h/mL) | Cmax (μg/mL) |
|---|---|---|
| 0.4 | 0.96 ± 0.34 | 0.05 ± 0.01 |
| 0.6 | 1.35 ± 0.15 | 0.06 ± 0.01 |
| 0.8 | 1.98 ± 0.35 | 0.11 ± 0.02 |
| 1.25 | 3.59 ± 0.69 | 0.22 ± 0.03 |
| 2.5 | 6.79 ± 0.35 | 0.38 ± 0.04 |
| 3.5 | 9.00 ± 0.73 | 0.45 ± 0.02 |
| 5 | 18.94 ± 3.34 | 1.13 ± 0.15 |
AUC24h, 24 h area under concentration–time curve; Cmax, maximum concentration. The AUC24h and Cmax were the mean values of five injections of danofloxacin at various dosages. Values are listed as mean ± SD.