Table 2.

Univariate and multivariate analysis for overall survival.

	Univariate analysis			Multivariate analysis
Variables	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Leukocytosis	1.502	1.277–1.766	<0.001	1.341	1.133–1.587	0.01
Male gender	0.949	0.82–1.098	0.479	NA
Age >70	1.811	1.541–2.128	<0.001	2.438	2.051–2.897	<0.001
T stage, T4	1.746	1.556–1.959	<0.001	1.352	1.103–1.657	0.004
N stage, N2	2.18	1.998–2.379	<0.001	1.48	1.321–1.657	<0.001
M1 stage	6.553	5.603–7.664	<0.001	4.952	4.173–5.875	<0.001
Grade(poor)	2.284	1.968–2.652	<0.001	1.423	1.207–1.677	<0.001
Lymph node examined (>12)	0.782	0.670–0.913	0.02	0.752	0.639–0.884	0.001
Mucinous Adenocarcinoma	1.624	1.269–2.078	<0.001	1.239	0.986–1.557	0.066
Perineural invasion	2.502	2.150–2.911	<0.001	1.373	1.162–1.622	<0.001
Vascular invasion	3.119	2.696–3.609	<0.001	1.628	1.370–1.935	<0.001
Adjuvant therapy	4.114	3.013–5.618	<0.001	0.833	0.480–1.445	0.515
Rectal cancer	0.763	0.660–0.882	<0.001	0.9	0.770–1.050	0.181
GPS (2)	1.491	1.305–1.703	<0.001	1.332	1.156–1.534	<0.001