Table 3.

Univariate and Multivariate analyzes of prognostic factors for disease-free survival.

	Univariate analysis			Multivariate analysis
Variables	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Leukocytosis	1.284	1.131–1.458	<0.001	1.146	1.006–1.305	0.04
Male gender	1.035	0.927–1.156	0541	NA
Age >70	1.325	1.132–1.552	<0.001	0.965	0.818–1.138	0.668
T stage, T4	1.752	1.607–1.909	<0.001	1.76	1.021–3.033	0.042
N stage, N2	2.04	1.912–2.177	<0.001	1.348	1.241–1.465	<0.001
M1 stage	8.157	7.304–9.108	<0.001	5.656	5.002–6.397	<0.001
Grade, poor	1.168	0.788–1.730	<0.001	1.064	0.941–1.203	0.323
LN examined >12	0.849	0.755–0.955	0.006	0.803	0.710–0.908	<0.001
Mucinous Adenocarcinoma	1.138	0.920–1.409	0.233	NA
Perineural invasion	2.426	2.163–2.722	<0.001	1.316	1.161–1.492	<0.001
Vascular invasion	2.308	2.065–2.579	<0.001	1.151	1.010–1.311	0.035
Adjuvant therapy	5.582	4.280–7.280	<0.001	1.97	1.335–2.907	0.001
Rectal cancer	0.847	0.767–0.935	0.001	1.049	0.944–1.165	0.376
GPS (2)	1.18	1.048–1.327	0.006	1.128	1.0–1.273	0.05