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. 2018 Sep 23;194(2):220–230. doi: 10.1111/cei.13161

Figure 4.

Figure 4

MiR‐146a directly targeted cyclin‐dependent kinase inhibitor 1A (CDKN1A). (a) Relative miR‐146a expression in synovium samples was higher in the rheumatoid arthritis (RA) group compared with the healthy control (HC) group. (b) Relative miR‐146a expression and relative CDKN1A expression showed a negative correlation in synovium samples. (c) The level of miR‐146a was also found higher in human fibroblast‐like synoviocytes (HFLS)‐RA than that in HFLS. (d) Luciferase activity decreased only in the CDKN1‐wild‐type (WT)+ miR‐146a group. (e) After transfected with anti‐146a, the level of miR‐146a was suppressed in HFLS‐RA. (f) The expression of CDKN1A mRNA was promoted. (g) The expression of CDKN1A protein was up‐regulated in the anti‐146a group while anti‐146a+ CDKN1A– reversed it. *P < 0·05; **P < 0·01.