Table 1.
Familial relative risks of myeloid malignancies
| Disease | Hematologic malignancy in first-degree relative | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Myeloid malignancy | MPN | PV | Essential thrombocythemia | Myelofibrosis | MPN NOS | Chronic myeloid leukemia | MDS | AML | ||||||||||
| No. | SIR (95% CI) | No. | SIR (95% CI) | No. | SIR (95% CI) | No. | SIR (95% CI) | No. | SIR (95% CI) | No. | SIR (95% CI) | No. | SIR (95% CI) | No. | SIR (95% CI) | No. | SIR (95% CI) | |
| Myeloid malignancy | 479 | 1.99 (1.81-2.17) | 265 | 2.86 (2.52-3.22) | 131 | 3.21 (2.69-3.81) | 76 | 2.73 (2.15-3.42) | 25 | 2.49 (1.61-3.67) | 33 | 2.50 (1.72-3.51) | 39 | 1.06 (0.76-1.45) | 59 | 2.31 (1.76-2.98) | 120 | 1.38 (1.15-1.65) |
| MPN | 267 | 2.79 (2.47-3.15) | 181 | 4.93 (4.24-5.70) | 94 | 5.76 (4.66-7.05) | 54 | 4.97 (3.74-6.49) | 11 | 2.76 (1.38-4.93) | 21 | 4.05 (2.51-6.20) | 20 | 1.37 (0.84-2.12) | 22 | 2.19 (1.37-3.32) | 47 | 1.36 (1.00-1.81) |
| PV | 133 | 3.23 (2.70-3.83) | 94 | 5.92 (4.78-7.24) | 53 | 7.66 (5.74-10.02) | 24 | 5.02 (3.22-7.47) | 7 | 4.00 (1.61-8.24) | 10 | 4.35 (2.08-8.00) | 8 | 1.28 (0.55-2.53) | 7 | 1.57 (0.63-3.23) | 26 | 1.77 (1.15-2.59) |
| Essential thrombocythemia | 78 | 2.65 (2.10-3.31) | 56 | 4.99 (3.77-6.48) | 23 | 4.53 (2.87-6.79) | 22 | 6.30 (3.95-9.54) | 3 | 2.48 (0.51-7.25) | 8 | 5.13 (2.21-10.10) | 5 | 1.12 (0.36-2.62) | 4 | 1.31 (0.36-3.36) | 13 | 1.21 (0.65-2.08) |
| Myelofibrosis | 26 | 2.51 (1.64-3.68) | 11 | 2.75 (1.37-4.92) | 7 | 3.93 (1.58-8.10) | 3 | 2.54 (0.52-7.43) | 0 | 1 | 1.79 (0.05-9.95) | 2 | 1.27 (0.15-4.57) | 9 | 8.33 (3.81-15.82) | 4 | 1.08 (0.29-2.76) | |
| MPN NOS | 33 | 2.21 (1.52-3.11) | 21 | 3.87 (2.39-5.91) | 10 | 4.03 (1.93-7.42) | 8 | 5.06 (2.19-9.98) | 1 | 1.72 (0.04-9.61) | 2 | 2.74 (0.33-9.90) | 5 | 2.25 (0.73-5.26) | 3 | 2.16 (0.45-6.31) | 4 | 0.77 (0.21-1.97) |
| Chronic myeloid leukemia | 39 | 1.11 (0.79-1.51) | 20 | 1.47 (0.90-2.27) | 8 | 1.38 (0.60-2.72) | 5 | 1.21 (0.39-2.82) | 2 | 1.34 (0.16-4.85) | 5 | 2.27 (0.74-5.30) | 4 | 0.78 (0.21-1.99) | 5 | 1.25 (0.40-2.91) | 11 | 0.88 (0.44-1.57) |
| MDS | 60 | 2.15 (1.64-2.76) | 21 | 1.96 (1.21-3.00) | 7 | 1.42 (0.57-2.92) | 4 | 1.29 (0.35-3.29) | 8 | 7.02 (3.03-13.83) | 3 | 2.14 (0.44-6.26) | 5 | 1.11 (0.36-2.59) | 18 | 6.87 (4.07-10.86) | 16 | 1.57 (0.90-2.55) |
| AML | 120 | 1.43 (1.19-1.71) | 47 | 1.46 (1.07-1.94) | 26 | 1.87 (1.22-2.73) | 13 | 1.32 (0.70-2.26) | 4 | 1.15 (0.31-2.93) | 4 | 0.86 (0.23-2.19) | 11 | 0.87 (0.43-1.55) | 16 | 1.77 (1.01-2.88) | 46 | 1.53 (1.12-2.04) |
NOS, not otherwise specified.