Table 1.

Participant timeline

Time (weeks)

>−1

0

1

2

3

4

8

12

16

17–20

21

22

23

24

28

32

36

Screening

x

Randomisation

x

Drug-titration period

x

x

x

x

x

x

x

x

Clinical visit+blood samples

x

x

x

x

x

x

x

x

x

Telephone call

x

x

x

x

x

x

Continuous glucose monitoring

x

x

x

Meal and bicycle test

x

x

x

Washout

x

Colours: grey: screening, randomisation and washout period; blue: treatment period 1: glimepiride+linagliptin or glimepiride+placebo; orange: treatment period 2: the opposite treatment of period 1.