Table 2.

Adverse Events (AEs) Following Treatment for Lymphatic Filariasis

	DEC/ALB (N=91)	IVM/DEC/ALB (N=41)
	Number of participants with AEs (percent)
At least one AE	37 (41)	24 (59)
Individuals with two or more AEs	24 (26)	19 (46)*
Fever§	19 (21)	14 (34)
Hemodynamic changes¶	4 (4)	5 (12)
Overall Grade 1 AEs (subjective)†	36 (40)	22 (54)
Overall Grade 2 and 3 AEs with severity grade >1†	5 (5)	11 (27)***
Frequency of AEs with severity grade >1
Fatigue	5 (5)	8 (20)
Headache	3 (3)	7 (17)
Nausea/vomiting	2	4 (10)
Itch/rash	0	2 (5)
Muscle ache	3 (3)	5 (12)
Eye swelling	0	1 (2)
Scrotal pain/swelling	2 (2)	4 (10)
Dyspnea	0	2 (5)

^*p<0.05

^§Auricular temperature ≥37.5°C. The highest temperature recorded post-treatment was 41.1°C.

^¶Defined as a change in blood pressure of 30 mm Hg systolic or 20 mm Hg diastolic compared to the pre-treatment recording. Three of five individuals in the IVM+DEC+ALB group had reduced blood pressure. All four individuals in the DEC+ALB group had reduced blood pressure.

^†Only grade 2 or 3 AEs are listed by symptoms. All but one participant with grade 2 symptoms had more than one AE.

^***p<0.001 by chi-square