Table 3.

Parameters independently associated with severe exacerbations/ hospitalizations; n = 357

	OR (95% CI) crude	OR (95% CI) adjusted
Gender
Female	Reference	Reference
Male	0.89 (0.58; 1.38)	0.95 (0.57; 1.57)
Age (years)
<  50	Reference	Reference
50–60	1.68 (0.56; 5.06)	0.87 (0.26; 2.90)
60–70	2.12 (0.74; 6.07)	1.00 (0.32; 3.13)
> 70	1.12 (0.39; 3.21)	0.71 (0.22; 2.24)
FEV1
> 80% pred.	Reference	Reference
50–80% pred.	0.86 (0.39; 1.88)	0.94 (0.40; 2.24)
30–50% pred.	2.09 (0.92; 4.75)	2.50 (1.02; 6.13)
< 30% pred.	10.69 (2.99;38.24)	13.62 (3.11; 59.63)
Smoking status
Current smoker	Reference	Reference
Former smoker	1.11 (0.71; 1.73)	1.19 (0.70; 2.02)
Never smoker	0.67 (0.21; 2.12)	0.82 (0.23; 2.92)
Adherence to therapy
Complete (≥ 80%)	Reference	Reference
Partial (50–80%)	0.77 (0.44; 1.35)	0.95 (0.50; 1.78)
Low (<  50%)	0.44 (0.27; 0.71)	0.58 (0.33; 1.02)