Table 2.
Treatment Options for Functional Laryngeal Disorder
| Medication | Type of Study | Dose of Medication | Number of Patients | Response Rate |
|---|---|---|---|---|
| Gabapentin | RCT (primary symptom cough) | Up to 1800 mg/day | 62 (32 treatment, 30 placebo) | 74%71 |
| Case series (primary symptom cough) | 100 to 900 mg/day | 28 | 68%69 | |
| Pregabalin | Case series (laryngeal symptoms) | 75 mg BID, increased to 150 mg BID over 4 weeks | 12 | 83%74 |
| Amitriptyline | RCT (primary symptom cough) | 10 mg up to 100 mg at night | 28 (15 amitriptyline, 13 guaifenesin) | 87%72 |
| Case series (primary symptom cough) | 10 mg up to 40 mg at night | 18 | 77%76 |
BID, twice daily; RCT, randomized, controlled trial.