Fig. 1.

Not all CORUM gold standard interactions are supported by co-fractionation data. a Example gold standard pair with strong evidence for interaction. Q9NQP4 and E5RGS4, prefoldin complex. b Example gold standard pair with evidence for interaction. Q14103 and O75534, PIN1-AUF1 complex. c Example gold standard protein pair with little data-derived evidence for interaction. P11021 and P07900, HCF-1 complex. d Histogram of Pearson correlation coefficients and e Euclidean distance between every gold standard interaction in our co-fractionation data (20 datasets, grey; average, black). All other protein pairs in our data are shown, the vast majority of which are not interacting (red). Example pairs A, B, C are shown (arrows)