Table 1.
Effect of MECN on hole cross test
| Treatment | Dose (mg/kg) | Number of hole crossed (% of Inhibition) | ||||
|---|---|---|---|---|---|---|
| Pretreatment | 30 min | 60 min | 90 min | 120 min | ||
| Control | 0.1 ml/mouse | 23.40 ± 1.21 | 18.60 ± 1.44 | 18.20 ± 1.36 | 17.00 ± 1.22 | 15.60 ± 1.08 |
| Diazepam | 1 | 21.40 ± 2.32 | 6.20 ± 1.07*** (66.67) | 3.80 ± 0.58*** (79.12) | 2.60 ± 0.51*** (84.71) | 1.40 ± 0.24*** (91.03) |
| MECN | 50 | 22.80 ± 1.28 | 15.40 ± 0.93 (17.20) | 11.80 ± 0.73*** (35.16) | 7.80 ± 0.86*** (54.12) | 6.00 ± 0.71*** (61.54) |
| MECN | 100 | 20.60 ± 1.86 | 10.60 ± 0.75*** (43.01) | 9.00 ± 0.71*** (50.55) | 4.60 ± 0.93*** (72.94) | 3.80 ± 0.86*** (75.64) |
| MECN | 200 | 21.20 ± 1.85 | 8.00 ± 0.71*** (56.99) | 5.20 ± 0.73*** (71.43) | 2.40 ± 0.51*** (85.88) | 1.60 ± 0.24*** (89.74) |
Effect of MECN on hole cross test. Values are presented as the Mean ± SEM (n = 5). MECN = Methanolic extract of Crataeva nurvala; ***p < 0.001 compared with the control group (two-way ANOVA followed by Bonferroni’s test)