Table 2.
Effect of MECN on open field test
| Treatment | Dose (mg/kg) | Number of square crossed (% of Inhibition) | ||||
|---|---|---|---|---|---|---|
| Pretreatment | 30 min | 60 min | 90 min | 120 min | ||
| Control | 0.1 ml/mouse | 103.80 ± 3.51 | 94.40 ± 4.31 | 83.20 ± 3.09 | 74.60 ± 3.20 | 66.80 ± 2.58 |
| Diazepam | 1 | 101.60 ± 3.89 | 49.20 ± 2.13*** (47.88) | 33.20 ± 1.88*** (60.10) | 14.80 ± 1.28*** (80.16) | 5.40 ± 1.12*** (91.92) |
| MECN | 50 | 98.00 ± 2.83 | 67.40 ± 3.79*** (28.60) | 42.00 ± 2.49*** (49.52) | 31.60 ± 2.87*** (57.64) | 16.20 ± 2.40*** (75.75) |
| MECN | 100 | 100.80 ± 2.62 | 46.40 ± 2.75*** (50.85) | 35.80 ± 2.48*** (56.97) | 16.20 ± 4.53*** (78.28) | 5.60 ± 0.75*** (91.62) |
| MECN | 200 | 102.20 ± 3.44 | 34.40 ± 3.23*** (63.56) | 22.20 ± 3.88*** (73.32) | 10.80 ± 2.89*** (85.52) | 4.20 ± 0.58*** (93.71) |
Effect of MECN on open field test. Values are presented as the Mean ± SEM (n = 5). MECN = Methanolic extract of Crataeva nurvala; ***p < 0.001 compared with the control group (two-way ANOVA followed by Bonferroni’s test)