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. 2018 Oct 19;19:190. doi: 10.1186/s12881-018-0695-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Localization of wild-type and R12L mutated αA-crystallin proteins. Photomicrographs show the distribution of immunoreactive αA-crystallin (green) and DAPI-stained nuclei (blue) in HeLa cells. Both wild-type CRYAA and mutated R12L-CRYAA proteins were predominantly localized in the cytoplasm. Cells transfected with wild-type CRYAA showed a homogenous distribution of the protein in the cytoplasm and there was little or no aggregation in the cells. In contrast, the cells transfected with the mutant R12L-CRYAA showed significant intracellular aggregation in a number of cells