Figure 1.

OS pathways in human endocrine neoplasia. Oxidative pathway and Sod2 expression was analyzed in different endocrine tumors. (A) Deregulation of OS genes in FTC compared with follicular adenoma, analyzed from microarray data. Significantly altered genes above cutoff (P < 0.01) are indicated by red circles; those below cutoff are indicated by gray circles; Sod2 is indicated by an arrow. (B) Expression of Sod2 in PTC compared with normal tissue (left), and matched primary tissue vs metastatic tissue (right). (C) Analysis of Sod2 expression in ATC compared with poorly differentiated thyroid cancer. (D) Kaplan-Meier survival curves of data from patients with ATC, based on low (red line) and high (green line) expression. (E) Kaplan-Meier survival curves of data from patients with ACC based on low (red line) and high (green line) expression. P value was calculated by log-rank test in survival analysis. Sources of microarray data for these analyses are described in Methods. **P < 0.01. ns, not significant; RSEM, RNA-sequencing by expectation-maximization.