Table 1.
Baseline Characteristics of the Southern Alberta Cohort Hospitalized With Heart Failure, According to Kidney Function at Time of Discharge.
| Baseline characteristics | eGFR ⩾ 90 (N = 141) | 60 < eGFR < 90 (N = 468) | 45 < eGFR < 60 (N = 329) | 30 < eGFR < 45 (N = 254) | eGFR < 30 (N = 212) | P value | Overall (N = 1404) |
|---|---|---|---|---|---|---|---|
| Sex (N(%), male) | 94 (66.67) | 319 (68.16) | 205 (62.31) | 146 (57.48) | 123 (58.02) | .019 | 887 (63.18) |
| Median age (IQR) | 58.53 (50.34, 64.46) | 68.34 (59.89, 77.85) | 75.15 (67.39, 82.01) | 79.57 (72.14, 84.07) | 76 .91 (67.88, 82.81) | <.0001 | 72.86 (62.56, 80.72) |
| eGFR (median, IQR) | 97.97 (93.67, 105.04) | 72.64 (65.98, 81.53) | 52.53 (49.22, 55.92) | 38.40 (34.59, 41.67) | 21.96 (15.72, 26.63) | <.0001 | 55.35 (39.26, 74.21) |
| Diabetes (N(%) | 44 (31.21) | 131 (27.99) | 118 (35.87) | 115 (45.28) | 124 (58.49) | <.0001 | 532 (37.89) |
| Hypertension | 68 (48.23) | 280 (59.83) | 233 (70.82) | 176 (69.29) | 181 (85.38) | <.0001 | 938 (66.81) |
| Death during follow-up | 34 (24.11) | 140 (29.91) | 140 (42.55) | 146 (57.48) | 132 (62.26) | <.0001 | 592 (42.17) |
| Blood pressure (mean, SD) (mmHG) | 1.63 (1.49, 1.80) | 1.63 (1.48, 1.85) | 1.75 (1.57, 2.00) | 1.78 (1.61, 2.05) | 1.83 (1.56, 2.11) | 1.71 (1.51, 1.96) | |
| Heart rate (mean, SD) (beats/min) | 96 (76, 113) | 91 (74, 110) | 84 (69, 100) | 79 (68, 96) | 77 (65.0) | <.0001 | 89.27 (25.93) |
| Hyperlipidemia | 79 (56.03) | 256 (54.70) | 185 (56.23) | 151 (59.45) | 149 (70.28) | .003 | 820 (58.40) |
| BMI (Mean, SD) | 28.96 (24.30, 35.99) | 28.40 (24.90, 32.98) | 28.41 (25.39, 33.91) | 27.41 (23.50, 31.65) | 27.68 (24.49, 32.46) | .11 | 30.05 (13.90) |
| Liver disease | 5 (3.55) | 7 (1.50) | 9 (2.74) | 1 (0.39) | 7 (3.30) | .09 | 29 (2.07) |
| GI disease | 4 (2.84) | 38 (8.12) | 34 (10.33) | 36 (14.17) | 34 (16.04) | .0002 | 146 (10.40) |
| Smoking | <.001 | ||||||
| Unknown | 25 (17.73) | 116 (24.79) | 99 (30.09) | 58 (22.83) | 42 (19.81) | 340 (24.22) | |
| Never | 36 (25.53) | 93 (19.87) | 73 (22.19) | 79 (31.10) | 67 (31.60) | 348 (24.79) | |
| Current | 42 (29.79) | 91 (19.44) | 35 (10.64) | 24 (9.45) | 23 (10.85) | 215 (15.31) | |
| Former | 38 (26.95) | 168 (35.90) | 122 (37.08) | 93 (36.61) | 80 (37.74) | 501 (35.68) | |
| Prior Infarction | 28 (10.04) | 111 (23.72) | 91 (27.66) | 104 (40.94) | 88 (41.51) | <.0001 | 422 (30.06) |
| Prior PCI | 20 (14.18) | 73 (15.60) | 58 (17.63) | 72 (28.35) | 65 (30.66) | <.0001 | 288 (20.51) |
| Prior CABG | 12 (8.51) | 68 (14.53) | 64 (19.45) | 58 (22/83) | 50 (22.58) | .0003 | 252 (17.95) |
| Peripheral Vascular | 2 (1.42) | 23 (4.91) | 25 (7.60) | 16 (6.30) | 23 (10.85) | .004 | 89 (6.34) |
| Cerebrovascular | 4 (2.84) | 43 (9.19) | 33 (10.03) | 32 (12.60) | 32 (15.09) | .003 | 144 (10.26) |
| Malignancy | 9 (6.38) | 23 (4.91) | 16 (4.86) | 23 (9.06) | 13 (6.13) | .019 | 84 (5.98) |
| Psychiatric history | 8 (5.67) | 12 (2.56) | 12 (3.65) | 9 (3.54) | 10 (4.72) | .417 | 51 (3.63) |
| History of alcoholism | 17 (12.06) | 36 (7.69) | 12 (3.65) | 3 (1.18) | 11 (5.19) | <.0001 | 79 (5.63 |
Note. eGFR = estimated glomerular filtration rate; BMI = body mass index; IQR = interquartile range; CABG = Coronary artery bypass grafting; GI = gastrointestinal; PCI = Percutaneous Coronary Intervention.