Fig. 5. Evaluation of RDSB analogue 11k in a mouse model of skin infection. A) BALB/c mice were intradermally challenged with an inoculum mixture containing 1 × 108 CFU of MRSA (JCSC 4788) along with 40 μg of the vehicle control (DMSO) or 40 μg of 11k or vancomycin. Representative images of the resulting cutaneous injuries sustained in the antibiotic and vehicle control mice are shown for 3 days and 8 days post-infection (scale in cm), respectively. B) A single 40 μg dose of 11k or vancomycin profoundly attenuated dermatopathology following cutaneous MRSA (JCSC 4788) challenge. C) A single 40 μg dose of 11k or vancomycin reduced morbidity as measured by animal weight. Error bars represent the standard deviation, n = 6.
