Table 1. In vitro antibacterial evaluation (MIC) of RDSB analogues 11a–11v against MRSA (JCSC 4788) and standard SA (ATCC 6538).
Comp. | R | MICMRSA μg mL–1 | MICSA μg mL–1 | Comp. | R | MICMRSA μg mL–1 | MICSA μg mL–1 |
11a | — | 256 | >256 | 11l | n-C8H17 | 0.5 | 0.25 |
11b | H | 128 | 128 | 11m | n-C9H19 | 0.50 | 0.50 |
11c | CH3 | 4.0 | 4.0 | 11n | n-C10H21 | 1.0 | 1.0 |
11d | C2H5 | 2.0 | 2.0 | 11o | n-C11H23 | 8.0 | 8.0 |
11e | n-C3H7 | 2.0 | 2.0 | 11p | n-C13H27 | 256 | 128 |
11f | i-C3H7 | 4.0 | 4.0 | 11q | n-C15H31 | >256 | >256 |
11g | n-C4H9 | 1.0 | 0.5 | 11r | c-C4H7 | 8.0 | 4.0 |
11h | i-C4H9 | 1.0 | 0.5 | 11s | c-C5H9 | 4.0 | 4.0 |
11i | n-C5H11 | 0.5 | 0.5 | 11t | c-C6H11 | 4.0 | 2.0 |
11j | n-C6H13 | 0.5 | 0.25 | 11u | CH2Ph | 4.0 | 4.0 |
11k | n-C7H15 | 0.25 | 0.25 | 11v | C2H4Ph | 2.0 | 2.0 |
1 | — | 1.0 | 1.0 | Van. | — | 1.0 | 0.5 |