TABLE 2:

CD Genetic Burden in the VEO, LO, and Intermediate Groups

	Groups of Age at Diagnosis	No.	PRS, Mean±SD	Beta (95% CI)a	P
Cedars cohort	VEO	36	0.37 ± 0.81	–0.14 (–0.45 to 0.16)	0.36
	Intermediate	2212	0.55 ± 0.96	–	–
	LO	106	0.15 ± 0.92	–0.40 (–0.57 to –0.21)	2.99E-05
IIBDGC	VEO	37	0.53 ± 0.85	0.15 (–0.2 to 0.39)	0.51
	Intermediate	12,183	0.48 ± 0.92	–	–
	LO	845	0.25 ± 0.96	–0.21 (–0.28 to –0.15)	1.35E-11

VEO, age at diagnosis <5 years; Intermediate group, 5 years ≤ age at diagnosis < 55 years; LO, age at diagnosis ≥55 years.

^aCompared with the intermediate group.