Fig. 4.
Voxelwise results of age-related changes in WMTI (red), DTI (blue), and DKI (green) metrics. Percentage of white matter skeleton voxels that (A1) significantly correlated with age and (B1) significantly changed with age over time, for each metric, where filled bars = positive correlations/increase and empty bars = negative correlations/decrease. TBSS results indicating voxels that (A2) significantly correlated with age and (B2) significantly changed, for each metric, where left brain = view from right and right brain = superior view. Abbreviations: AWF, axonal water fraction; De,⊥, extraaxonal diffusivity in the radial direction; DKI, diffusional kurtosis imaging; DTI, diffusion tensor imaging; FA, fractional anisotropy; MD, mean diffusivity; MK, mean kurtosis; WMTI, white matter tract integrity. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)