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. 2018 Oct 19;13(10):e0205105. doi: 10.1371/journal.pone.0205105

Table 2. Age-standardised anal cancer incidence rates (per 100,000 individuals), 5-year average percent change and standardised rate ratios compared to 1988–1992 in selected high income countries: All histological types.

Sex Continent/Country All ages <60 years 60+ years
ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992		 ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992		 ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992
Male (a) Overall (7 countries including Canada, USA, 4 European countries and Australia)
Overall 0.63 0.85 8.3%
(6.2%, 10.4%)
P = 0.001 		1.35
(1.28–1.42)		 0.28 0.49 16.4%
(12.2%, 20.8%)
P = 0.001 		1.77
(1.62–1.92)		 3.51 3.78 2.0%
(1.0%, 2.9%)
P = 0.01 		1.08
(1.00–1.15)
(b) By continent
North America 0.76 0.97 6.9%
(1.0%, 13.2%)
P = 0.03 		1.28
(1.18–1.38)		 0.33 0.59 15.3%
(8.9%, 22.1%)
P = 0.004 		1.77
(1.57–1.98)		 4.23 4.08 0.0%
(-6.4%, 6.8%)
P = 1.0 		0.97
(0.87–1.07)
Europe 0.51 0.71 9.0%
(3.4%, 15.0%)
P = 0.01 		1.39
(1.27–1.51)		 0.21 0.38 17.7%
(11.4%, 24.2%)
P = 0.002 		1.78
(1.54–2.07)		 2.93 3.38 3.1%
(-4.2%, 10.9%)
P = 0.3 		1.15
(1.03–1.29)
Oceaniac 0.64 0.90 9.3%
(6.6%, 12.1%)
P = 0.001 		1.41
(1.22–1.63)		 0.31 0.50 15.1%
(6.0%, 24.9%)
P = 0.01 		1.62
(1.30–2.02)		 3.31 4.16 5.0%
(-3.9%, 14.7%)
P = 0.2 		1.26
(1.04–1.51)
(c) By country
Canada 0.85 0.85 1.1%
(-8.4%, 11.5%)
P = 0.8 		0.99
(0.89–1.11)		 0.29 0.43 9.9%
(-2.4%, 23.7%)
P = 0.1 		1.47
(1.23–1.77)		 5.34 4.18 -4.4%
(-13.3%, 5.4%)
P = 0.2 		0.78
(0.68–0.90)
USA 0.67 1.09 13.0%
(10.4%, 15.6%)
P = 0.0004 		1.62
(1.45–1.80)		 0.37 0.73 19.4%
(15.8%, 23.2%)
P = 0.0004 		1.99
(1.72–2.31)		 3.15 3.99 5.9%
(2.5%, 9.3%)
P = 0.01 		1.27
(1.08–1.48)
Denmark 0.53 0.82 10.3%
(5.4%, 15.5%)
P = 0.01 		1.54
(1.22–1.96)		 0.20 0.45 16.2%
(-1.4%, 37.0%)
P = 0.1 		2.29
(1.51–3.47)		 3.26 3.84 4.5%
(-6.8%, 17.2%)
P = 0.3 		1.18
(0.89–1.56)
France 0.69 0.59 -4.1%
(-13.8%, 6.7%)
P = 0.3 		0.86
(0.64–1.16)		 0.25 0.33 9.1%
(0.7%, 18.1%)
P = 0.04 		1.31
(0.80–2.14)		 4.18 2.68 -12.9%
(-25.8%, 2.3%)
P = 0.1 		0.64
(0.44–0.93)
The Netherlands 0.34 0.60 19.7%
(5.8%, 35.3%)
P = 0.02 		1.77
(1.48–2.13)		 0.17 0.31 21.9%
(2.3%, 45.3%)
P = 0.04 		1.80
(1.36–2.39)		 1.68 2.95 17.8%
(6.7%, 29.9%)
P = 0.01 		1.75
(1.38–2.22)
UK 0.57 0.78 7.8%
(3.3%, 12.4%)
P = 0.01 		1.37
(1.21–1.55)		 0.24 0.43 17.8%
(11.1%, 25.0%)
P = 0.003 		1.81
(1.47–2.23)		 3.27 3.64 1.0%
(-5.3%, 7.7%)
P = 0.7 		1.12
(0.96–1.30)
Australia 0.64 0.90 9.3%
(6.6%, 12.1%)
P = 0.001 		1.41
(1.22–1.63)		 0.31 0.50 15.1%
(6.0%, 24.9%)
P = 0.01 		1.62
(1.30–2.02)		 3.31 4.16 5.0%
(-3.9%, 14.7%)
P = 0.2 		1.26
(1.04–1.51)
Female (a) Overall (7 countries including Canada, USA, 4 European countries and Australia)
Overall 0.70 1.22 15.8%
(12.0%, 19.7%)
P = 0.001 		1.75
(1.67–1.83)		 0.31 0.71 23.8%
(18.0%, 30.0%)
P = 0.001 		2.31
(2.14–2.48)		 3.88 5.37 8.9%
(3.0%, 15.2%)
P = 0.02 		1.38
(1.31–1.46)
(b) By continent
North America 0.86 1.32 13.0%
(8.1%, 18.1%)
P = 0.003 		1.54
(1.44–1.65)		 0.38 0.74 19.8%
(11.1%, 29.2%)
P = 0.005 		1.98
(1.78–2.19)		 4.75 6.00 7.2%
(1.6%, 13.1%)
P = 0.03 		1.26
(1.16–1.37)
Europe 0.56 1.13 18.7%
(13.4%, 24.2%)
P = 0.001 		2.02
(1.88–2.18)		 0.24 0.67 27.9%
(20.3%, 35.9%)
P = 0.001 		2.84
(2.51–3.21)		 3.15 4.82 10.6%
(2.9%, 18.9%)
P = 0.02 		1.53
(1.40–1.68)
Oceaniac 0.72 1.22 16.1%
(5.6%, 27.6%)
P = 0.02 		1.70
(1.50–1.92)		 0.33 0.72 25.3%
(8.8%, 44.2%)
P = 0.01 		2.18
(1.79–2.66)		 3.85 5.25 8.7%
(2.4%, 15.3%)
P = 0.02 		1.36
(1.17–1.59)
(c) By country
Canada 0.85 1.28 12.0%
(7.3%, 16.9%)
P = 0.004 		1.51
(1.37–1.66)		 0.38 0.71 19.2%
(8.2%, 31.2%)
P = 0.01 		1.87
(1.61–2.17)		 4.64 5.89 6.4%
(3.2%, 9.6%)
P = 0.01 		1.27
(1.13–1.43)
USA 0.87 1.36 13.8%
(7.8%, 20.2%)
P = 0.005 		1.57
(1.43–1.72)		 0.37 0.77 20.4%
(12.0%, 29.4%)
P = 0.004 		2.08
(1.80–2.40)		 4.87 6.10 7.7%
(-2.8%, 19.4%)
P = 0.1 		1.25
(1.12–1.40)
Denmark 0.73 1.73 20.9%
(11.1%, 31.5%)
P = 0.01 		2.37
(1.97–2.84)		 0.37 1.07 27.2%
(8.8%, 48.7%)
P = 0.02 		2.91
(2.19–3.87)		 3.68 7.10 14.0%
(1.7%, 27.9%)
P = 0.0 		1.93
(1.53–2.43)
France 1.05 1.40 6.9%
(0.9%, 13.3%)
P = 0.04 		1.33
(1.08–1.63)		 0.45 0.80 16.5%
(11.4%, 21.9%)
P = 0.0002 		1.76
(1.25–2.48)		 5.90 6.22 -0.2%
(-8.7%, 9.1%)
P = 0.9 		1.05
(0.82–1.35)
The Netherlands 0.30 0.68 22.9%
(20.3%, 25.5%)
P = 0.0001 		2.28
(1.91–2.72)		 0.10 0.44 37.8%
(24.6%, 52.3%)
P = 0.002 		4.41
(3.28–5.92)		 1.89 2.60 9.3%
(-0.1%, 19.5%)
P = 0.05 		1.37
(1.10–1.72)
UK 0.56 1.27 21.6%
(13.9%, 29.8%)
P = 0.002 		2.27
(2.04–2.52)		 0.24 0.74 29.1%
(19.2%, 39.9%)
P = 0.0002 		3.06
(2.56–3.66)		 3.13 5.55 14.9%
(6.4%, 24.1%)
P = 0.01 		1.78
(1.56–2.02)
Australia 0.72 1.22 16.1%
(5.6%, 27.6%)
P = 0.02 		1.70
(1.50–1.92)		 0.33 0.72 25.3%
(8.8%, 44.2%)
P = 0.01 		2.18
(1.79–2.66)		 3.85 5.25 8.7%
(2.4%, 15.3%)
P = 0.02 		1.36
(1.17–1.59)

ASR–age standardised rate; SRR–standardised rate ratio (compared to 1988–1992); 5-year AvPC–average percent change between successive 5-year periods.

a Incidence rates were age-standardised using the Segi 1960 World Standard Population.

b 5-year average percent change in the standardised incidence rates was estimated over the period 1988–1992, 1993–1997, 1998–2002, 2003–2007 and 2008–2012. Negative signs indicate decrease in the age-standardised rates over time.

c Oceania includes Australia only.

Note) Data are only included in the current analysis from cancer registries that reported for the entire period 1988–2012 and that also satisfied a priori conditions (see Materials and methods). Therefore, the age-standardised incidence rate of each country reported in the above table does not necessarily correspond to each country’s national statistics.