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. 2018 Oct 19;13(10):e0205105. doi: 10.1371/journal.pone.0205105

Table 3. Age-standardised incidence rates (per 100,000 individuals), 5-year average percent change and standardised rate ratios compared to 1988–1992 in selected high income countries: Squamous cell carcinoma of the anus.

Sex Continent/Country All ages <60 years 60+ years
ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992		 ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992		 ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992
Male (a) Overall (7 countries including Canada, USA, 4 European countries and Australia)
Overall 0.31 0.63 18.9%
(15.6%, 22.2%)
P = 0.0003 		2.00
(1.87–2.14)		 0.17 0.39 23.6%
(15.9%, 31.9%)
P = 0.002 		2.34
(2.11–2.58)		 1.50 2.53 13.8%
(12.4%, 15.2%)
P = 0.0001 		1.69
(1.54–1.86)
(b) By continent
North America 0.37 0.68 15.4%
(9.5%, 21.7%)
P = 0.003 		1.86
(1.68–2.05)		 0.20 0.46 20.5%
(10.2%, 31.8%)
P = 0.007 		2.28
(1.99–2.61)		 1.70 2.48 8.9%
(5.6%, 12.4%)
P = 0.003 		1.45
(1.26–1.68)
Europe 0.24 0.57 23.7%
(21.8%, 25.6%)
P = 0.00003 		2.32
(2.07–2.59)		 0.12 0.32 29.0%
(18.8%, 40.0%)
P = 0.002 		2.67
(2.23–3.19)		 1.27 2.59 19.1%
(13.7%, 24.7%)
P = 0.001 		2.05
(1.77–2.37)
Oceaniac 0.36 0.61 17.1%
(6.9%, 28.4%)
P = 0.01 		1.69
(1.41–2.03)		 0.20 0.38 21.0%
(6.8%, 37.1%)
P = 0.02 		1.85
(1.43–2.40)		 1.63 2.49 13.2%
(1.8%, 25.8%)
P = 0.03 		1.53
(1.19–1.97)
(c) By country
Canada 0.28 0.47 11.0%
(1.9%, 20.9%)
P = 0.03 		1.65
(1.40–1.95)		 0.14 0.28 14.1%
(-0.6%, 31.0%)
P = 0.1 		1.96
(1.54–2.49)		 1.43 2.01 7.4%
(0.6%, 14.7%)
P = 0.04 		1.41
(1.12–1.76)
USA 0.45 0.89 18.0%
(13.0%, 23.4%)
P = 0.001 		1.98
(1.75–2.24)		 0.26 0.64 23.9%
(15.6%, 32.8%)
P = 0.002 		2.44
(2.06–2.87)		 1.98 2.95 10.0%
(7.6%, 12.5%)
P = 0.001 		1.49
(1.23–1.81)
Denmark 0.34 0.69 19.7%
(13.4%, 26.3%)
P = 0.002 		2.03
(1.54–2.69)		 0.15 0.36 20.2%
(-4.0%, 50.4%)
P = 0.1 		2.47
(1.55–3.96)		 1.88 3.30 18.0%
(2.2%, 36.2%)
P = 0.03 		1.75
(1.25–2.47)
France 0.24 0.48 16.4%
(5.7%, 28.1%)
P = 0.02 		1.97
(1.31–2.96)		 0.11 0.28 26.5%
(6.5%, 50.1%)
P = 0.02 		2.53
(1.34–4.80)		 1.31 2.07 7.4%
(-6.2%, 23.0%)
P = 0.2 		1.58
(0.93–2.67)
The Netherlands 0.18 0.52 37.5%
(17.2%, 61.2%)
P = 0.01 		2.87
(2.31–3.57)		 0.11 0.28 36.0%
(10.4%, 67.5%)
P = 0.02 		2.62
(1.90–3.61)		 0.78 2.45 38.7%
(23.8%, 55.5%)
P = 0.003 		3.16
(2.35–4.25)
UK 0.25 0.58 20.4%
(13.4%, 27.7%)
P = 0.002 		2.30
(1.95–2.71)		 0.12 0.34 28.5%
(20.2%, 37.4%)
P = 0.001 		2.85
(2.19–3.70)		 1.35 2.57 28.5%
(20.2%, 37.4%)
P = 0.02 		1.91
(1.55–2.34)
Australia 0.36 0.61 17.1%
(6.9%, 28.4%)
P = 0.01 		1.69
(1.41–2.03)		 0.20 0.38 21.0%
(6.8%, 37.1%)
P = 0.02 		1.85
(1.43–2.40)		 1.63 2.49 13.2%
(1.8%, 25.8%)
P = 0.03 		1.53
(1.19–1.97)
Female (a) Overall (7 countries including Canada, USA, 4 European countries and Australia)
Overall 0.48 1.03 21.9%
(18.8%, 24.9%)
P = 0.0001 		2.15
(2.04–2.26)		 0.23 0.62 28.4%
(20.5%, 36.8%)
P = 0.001 		2.76
(2.54–3.00)		 2.51 4.28 15.2%
(7.7%, 23.2%)
P = 0.007 		1.70
(1.59–1.82)
(b) By continent
North America 0.58 1.08 17.5%
(13.6%, 21.6%)
P = 0.001 		1.84
(1.71–1.98)		 0.27 0.63 23.0%
(11.1%, 36.2%)
P = 0.008 		2.36
(2.10–2.65)		 3.16 4.70 11.9%
(4.3%, 20.0%)
P = 0.01 		1.49
(1.35–1.64)
Europe 0.37 0.99 26.6%
(20.7%, 32.9%)
P = 0.001 		2.67
(2.45–2.91)		 0.18 0.62 33.8%
(23.4%, 45.1%)
P = 0.001 		3.52
(3.07–4.03)		 1.94 3.99 19.1%
(10.7%, 28.1%)
P = 0.005 		2.06
(1.84–2.29)
Oceaniac 0.52 1.00 22.0%
(5.8%, 40.7%)
P = 0.02 		1.92
(1.67–2.22)		 0.27 0.64 30.6%
(10.0%, 55.1%)
P = 0.02 		2.40
(1.94–2.97)		 2.58 3.94 13.6%
(0.3%, 28.8%)
P = 0.05 		1.53
(1.26–1.84)
(c) By country
Canada 0.48 0.92 17.3%
(11.1%, 23.8%)
P = 0.003 		1.91
(1.70–2.14)		 0.23 0.54 22.3%
(6.8%, 40.1%)
P = 0.02 		2.35
(1.96–2.81)		 2.53 3.99 12.2%
(7.2%, 17.3%)
P = 0.004 		1.58
(1.36–1.84)
USA 0.68 1.22 17.8%
(11.9%, 24.0%)
P = 0.002 		1.80
(1.63–1.98)		 0.30 0.71 23.6%
(13.1%, 35.0%)
P = 0.005 		2.35
(2.02–2.75)		 3.75 5.39 11.7%
(-0.7%, 25.7%)
P = 0.06 		1.44
(1.26–1.63)
Denmark 0.58 1.54 24.5%
(15.2%, 34.6%)
P = 0.003 		2.64
(2.16–3.23)		 0.32 0.99 30.0%
(7.9%, 56.6%)
P = 0.02 		3.12
(2.30–4.22)		 2.73 5.99 17.6%
(2.6%, 34.9%)
P = 0.03 		2.19
(1.69–2.85)
France 0.72 1.26 14.2%
(7.5%, 21.2%)
P = 0.01 		1.75
(1.39–2.21)		 0.33 0.73 22.9%
(15.9%, 30.4%)
P = 0.002 		2.19
(1.51–3.20)		 3.85 5.54 7.0%
(-4.3%, 19.5%)
P = 0.1 		1.44
(1.08–1.91)
The Netherlands 0.17 0.60 35.3%
(31.1%, 39.7%)
P = 0.0001 		3.54
(2.87–4.36)		 0.06 0.41 46.2%
(25.8%, 69.9%)
P = 0.004 		6.50
(4.65–9.09)		 1.04 2.15 21.7%
(12.7%, 31.5%)
P = 0.004 		2.07
(1.58–2.71)
UK 0.35 1.08 30.6%
(20.9%, 41.1%)
P = 0.002 		3.07
(2.70–3.48)		 0.17 0.66 35.5%
(23.9%, 48.3%)
P = 0.002 		3.87
(3.16–4.72)		 1.83 4.51 25.2%
(13.5%, 38.1%)
P = 0.01 		2.47
(2.11–2.88)
Australia 0.52 1.00 22.0%
(5.8%, 40.7%)
P = 0.02 		1.92
(1.67–2.22)		 0.27 0.64 30.6%
(10.0%, 55.1%)
P = 0.02 		2.40
(1.94–2.97)		 2.58 3.94 13.6%
(0.3%, 28.8%)
P = 0.05 		1.53
(1.26–1.84)

ASR–age standardised rate; SRR–standardised rate ratio (compared to 1988–1992); 5-year AvPC–average percent change between successive 5-year periods.

a Incidence rates were age-standardised using the Segi 1960 World Standard Population.

b 5-year average percent change in the standardised incidence rates was estimated over the period 1988–1992, 1993–1997, 1998–2002, 2003–2007 and 2008–2012. Negative signs indicate decrease in the age-standardised rates over time.

c Oceania includes Australia only.

Note) Data are only included in the current analysis from cancer registries that reported for the entire period 1988–2012 and that also satisfied a priori conditions (see Materials and methods). Therefore, the age-standardised incidence rate of each country reported in the above table does not necessarily correspond to each country’s national statistics.