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. 2018 Oct 19;13(10):e0205105. doi: 10.1371/journal.pone.0205105

Table 4. Age-standardised incidence rates (per 100,000 individuals), 5-year average percent change and the standardised rate ratios compared to 1988–1992 in selected high income countries: Adenocarcinoma of the anus.

Sex Continent/ Country All ages <60 years 60+ years
ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992		 ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992		 ASRa
(1988–1992)		 ASRa
(2008–2012)		 5-year AvPCb
(95% CI)
P value		 SRR (95% CI)
2008–2012 vs 1988–1992
Male (a) Overall (7 countries including Canada, USA, 4 European countries and Australia)
Overall 0.24 0.14 -10.6%
(-18.7%, -1.7%)
P = 0.03 		0.60
(0.54–0.67)		 0.08 0.05 -8.2%
(-14.5%, -1.5%)
P = 0.03 		0.66
(0.54–0.81)		 1.55 0.88 -11.6%
(-21.0%, -1.0%)
P = 0.04 		0.57
(0.50–0.65)
(b) By continent
North America 0.33 0.18 -10.1%
(-27.6%, 11.5%)
P = 0.2 		0.53
(0.46–0.62)		 0.11 0.06 -8.0%
(-23.3%, 10.4%)
P = 0.2 		0.59
(0.44–0.79)		 2.16 1.10 -10.9%
(-29.7%, 12.8%)
P = 0.2 		0.51
(0.43–0.61)
Europe 0.16 0.09 -15.6%
(-25.5%, -4.4%)
P = 0.02 		0.54
(0.44–0.66)		 0.06 0.03 -13.4%
(-21.1%, -4.8%)
P = 0.02 		0.59
(0.40–0.88)		 1.04 0.54 -16.5%
(-27.5%, -3.9%)
P = 0.03 		0.52
(0.41–0.65)
Oceaniac 0.24 0.22 -4.0%
(-15.4%, 9.0%)
P = 0.4 		0.96
(0.74–1.24)		 0.08 0.08 -3.6%
(-17.5%, 12.6%)
P = 0.5 		0.98
(0.60–1.60)		 1.47 1.39 -4.2%
(-15.2%, 8.3%)
P = 0.3 		0.94
(0.70–1.28)
(c) By country
Canada 0.49 0.21 -11.7%
(-35.8%, 21.2%)
P = 0.3 		0.43
(0.35–0.51)		 0.14 0.06 -8.4%
(-37.4%, 33.9%)
P = 0.5 		0.45
(0.31–0.67)		 3.37 1.41 -12.9%
(-35.3%, 17.4%)
P = 0.2 		0.42
(0.34–0.52)
USA 0.17 0.14 -4.7%
(-7.7%, -1.6%)
P = 0.02 		0.83
(0.64–1.07)		 0.07 0.06 -3.0%
(-21.0%, 19.0%)
P = 0.7 		0.87
(0.56–1.35)		 0.97 0.78 -5.5%
(-12.8%, 2.5%)
P = 0.1 		0.80
(0.58–1.11)
Denmark 0.16 0.06 -24.3%
(-43.4%, 1.3%)
P = 0.1 		0.36
(0.19–0.67)		 0.04 0.03 -14.9%
(-42.9%, 26.8%)
P = 0.3 		0.84
(0.24–2.91)		 1.13 0.27 -28.2%
(-48.5%, 0.2%)
P = 0.1 		0.24
(0.11–0.50)
France 0.40 0.06 -39.5%
(-53.5%, -21.3%)
P = 0.01 		0.16
(0.08–0.29)		 0.11 0.02 -36.4%
(-52.2%, -15.3%)
P = 0.02 		0.19
(0.06–0.64)		 2.74 0.39 -40.8%
(-54.4%, -23.0%)
P = 0.01 		0.14
(0.07–0.29)
The Netherlands 0.12 0.05 -21.8%
(-32.5%, -9.3%)
P = 0.01 		0.44
(0.28–0.71)		 0.05 0.01 -29.1%
(-33.0%, -25.0%)
P = 0.0003 		0.27
(0.10–0.69)		 0.66 0.36 -18.3%
(-32.3%, -1.3%)
P = 0.04 		0.55
(0.32–0.95)
UK 0.14 0.13 -3.0%
(-11.9%, 6.7%)
P = 0.4 		0.91
(0.69–1.19)		 0.05 0.05 1.4%
(-5.7%, 9.0%)
P = 0.6 		0.99
(0.58–1.69)		 0.87 0.75 -5.1%
(-16.6%, 7.9%)
P = 0.3 		0.86
(0.63–1.19)
Australia 0.24 0.22 -4.0%
(-15.4%, 9.0%)
P = 0.4 		0.96
(0.74–1.24)		 0.08 0.08 -3.6%
(-17.5%, 12.6%)
P = 0.5 		0.98
(0.60–1.60)		 1.47 1.39 -4.2%
(-15.2%, 8.3%)
P = 0.3 		0.94
(0.70–1.28)
Female (a) Overall (7 countries including Canada, USA, 4 European countries and Australia)
Overall 0.16 0.10 -9.9%
(-17.6%, -1.4%)
P = 0.03 		0.63
(0.56–0.71)		 0.06 0.04 -9.7%
(-17.0%, -1.8%)
P = 0.03 		0.61
(0.47–0.78)		 0.96 0.61 -9.9%
(-18.9%, 0.0%)
P = 0.05 		0.64
(0.56–0.73)
(b) By continent
North America 0.22 0.11 -11.3%
(-24.9%, 4.8%)
P = 0.1 		0.52
(0.44–0.62)		 0.09 0.05 -10.6%
(-27.6%, 10.4%)
P = 0.2 		0.50
(0.36–0.70)		 1.27 0.67 -11.6%
(-25.8%, 5.2%)
P = 0.1 		0.53
(0.43–0.64)
Europe 0.10 0.07 -10.7%
(-19.6%, -0.8%)
P = 0.04 		0.71
(0.57–0.88)		 0.03 0.02 -13.4%
(-28.7%, 5.2%)
P = 0.1 		0.71
(0.43–1.16)		 0.68 0.49 -9.7%
(-16.6%, -2.2%)
P = 0.03 		0.72
(0.57–0.90)
Oceaniac 0.15 0.13 -5.2%
(-22.4%, 15.7%)
P = 0.5 		0.86
(0.63–1.17)		 0.04 0.04 -5.3%
(-27.5%, 23.7%)
P = 0.6 		0.86
(0.42–1.75)		 1.00 0.86 -5.2%
(-21.7%, 14.8%)
P = 0.4 		0.86
(0.62–1.20)
(c) By country
Canada 0.31 0.15 -10.8%
(-29.0%, 12.1%)
P = 0.2 		0.49
(0.39–0.61)		 0.13 0.06 -9.7%
(-32.9%, 21.4%)
P = 0.4 		0.48
(0.32–0.72)		 1.76 0.87 -11.5%
(-30.3%, 12.4%)
P = 0.2 		0.50
(0.39–0.63)
USA 0.14 0.08 -12.4%
(-18.3%, -6.2%)
P = 0.009 		0.57
(0.42–0.76)		 0.06 0.03 -12.1%
(-16.1%, -8.0%)
P = 0.003 		0.57
(0.33–0.99)		 0.83 0.47 -12.6%
(-21.4%, -2.8%)
P = 0.03 		0.57
(0.40–0.79)
Denmark 0.11 0.10 -5.6%
(-25.8%, 20.1%)
P = 0.5 		0.93
(0.54–1.60)		 0.04 0.03 -12.6%
(-42.3%, 32.5%)
P = 0.4 		0.74
(0.23–2.36)		 0.66 0.67 -2.6%
(-23.4%, 23.8%)
P = 0.8 		1.02
(0.56–1.87)
France 0.26 0.07 -33.9%
(-49.9%, -12.9%)
P = 0.02 		0.27
(0.14–0.50)		 0.10 0.04 -29.0%
(-55.7%, 13.6%)
P = 0.1 		0.39
(0.12–1.22)		 1.55 0.32 -36.4%
(-45.6%, -25.6%)
P = 0.003 		0.21
(0.10–0.43)
The Netherlands 0.11 0.04 -22.8%
(-32.9%, -11.1%)
P = 0.01 		0.39
(0.24–0.61)		 0.03 0.01 -19.9%
(-45.5%, 17.5%)
P = 0.2 		0.41
(0.14–1.23)		 0.75 0.28 -23.7%
(-30.9%, -15.7%)
P = 0.003 		0.38
(0.23–0.63)
UK 0.07 0.09 1.0%
(-20.5%, 28.3%)
P = 0.9 		1.36
(0.98–1.87)		 0.02 0.03 -4.0%
(-33.1%, 37.7%)
P = 0.7 		1.51
(0.68–3.37)		 0.46 0.61 2.4%
(-16.6%, 25.7%)
P = 0.7 		1.31
(0.94–1.83)
Australia 0.15 0.13 -5.2%
(-22.4%, 15.7%)
P = 0.5 		0.86
(0.63–1.17)		 0.04 0.04 -5.3%
(-27.5%, 23.7%)
P = 0.6 		0.86
(0.42–1.75)		 1.00 0.86 -5.2%
(-21.7%, 14.8%)
P = 0.4 		0.86
(0.62–1.20)

ASR–age standardised rate; SRR–standardised rate ratio (compared to 1988–1992); 5-year AvPC–average percent change between successive 5-year periods.

a Incidence rates were age-standardised using the Segi 1960 World Standard Population.

b 5-year average percent change in the standardised incidence rates was estimated over the period 1988–1992, 1993–1997, 1998–2002, 2003–2007 and 2008–2012. Negative signs indicate decrease in the age-standardised rates over time.

c Oceania includes Australia only.

Note) Data are only included in the current analysis from cancer registries that reported for the entire period 1988–2012 and that also satisfied a priori conditions (see Materials and methods). Therefore, the age-standardised incidence rate of each country reported in the above table does not necessarily correspond to each country’s national statistics.