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. 2018 Oct 19;13(10):e0205979. doi: 10.1371/journal.pone.0205979

Table 1. Study background characteristics of the ESTER birth cohort (births in Northern Finland during 1985–89): Clinical Examination during 2009–11.

Variable Subgroup Early Preterm <34 weeks Late preterm 34-<37 weeks Full-term ≥37weeks Missing (n)
n = 139 n = 239 n = 341 Early pretem/Late Preterm /Term
mean (SD)/n (%) mean (SD)/n (%) mean (SD)/n (%)
Maternal smoking during pregnancy a 23 (16.5%) 46 (19.2%) 54 (15.8%) 0/0/0
Highest parental education a Secondary or less or unknown 97 (69.8%) 159 (66.5%) 229 (67.2%) 0/0/0
Lower tertiary 13 (9.4%) 30 (12.6%) 44 (12.9%)
Upper tertiary 29 (20.9%) 50 (20.9%) 68 (19.9%)
Maternal body mass index before pregnancy b 22.5 (3.5) 22.7 (4.0) 22.3 (3.0) 8/7/13
Antenatal glucocorticoid treatmentc 20 (22.2%) 7 (6.5%) 0 (0%) 0/0/0
Maternal gestational diabetesd 4 (2.9%) 11 (4.6%) 6 (1.8%) 0/0/0
Hypertensive disorder during pregnancy Normotensivea 85 (63.0%) 167 (72.3%) 274 (84.3%) 4/8/16
Gestational hypertensiona 7 (5.2%) 20 (8.7%) 27 (8.3%)
Preeclampsiaa 23 (17.0%) 22 (9.5%) 8 (2.5%)
Chronic hypertension** 12 (8.9%) 16 (6.9%) 9 (2.8%)
Superimposed preeclampsia* 8 (5.9%) 6 (2.6%) 7 (2.2%)
Mean length of gestation (weeks)b 31.8 (1.9) 35.8 (0.8) 40.1 (1.2) 0/0/0
Maternal age at birthb 29.4 (5.4) 29.4 (6.0) 28.1 (5.5) 0/0/0
Multiple pregnancy (twins)d 33 (23.7%) 32 (13.4%) 4 (1.2%) 0/0/0
Source cohorta,e NFBC 49 (35.3%) 131 (54.8%) 205 (60.1%) 0/0/0
FMBR 90 (64.7%) 108 (45.2%) 136 (39.9%) 0/0/0
Sexa Male 66 (47.5%) 118 (49.4%) 164 (48.1%) 0/0/0
Female 73 (52.5%) 121 (50.6%) 177 (51.9%)
Birth weight (g)b 1777 (482) 2670 (521) 3583 (485) 0/0/0
Birth weight SD scoreb -0.72 (1.40) -0.64 (1.29) -0.00 (1.00) 0/0/0
SGA (birth weight<-2SD)a 22 (15.8%) 30 (12.6%) 6 (1.8%) 0/0/0
Bronchopulmonary dysplasiaf 12 (8.6%) 1 (0.4%) 0 (0%) 0/0/0
Respirator care Not treated in respirator 72 (51.8%) 210 (87.9%) 339 (99.4%) 0/0/0
<7 days 51 (36.7%) 26 (10.9%) 2 (0.6%)
7 to <14 days 9 (6.5%) 3 (1.3%) 0 (0%)
14 or more days 7 (5.0%) 0 (0%) 0 (0%)
Age at clinical examination (y)b 23.1 (1.4) 23.2 (1.2) 23.5 (1.1) 0/0/0
Height (cm) womenb 162.5 (6.2) 164.5 (5.7) 164.0 (5.8) 0/0/0
menb 178.2 (7.5) 177.7 (6.7) 177.8 (6.9) 0/0/0
BMI (kg/m2)g womenb 24.3 (5.8) 23.7 (4.3) 23.3 (4.3) 0/0/0
menb 24.2 (4.0) 25.3 (4.7) 24.3 (4.3) 0/0/0
Obesity (BMI: 30≥kg/m2) womenb 12 (16.4%) 9 (7.4%) 17 (9.6%) 0/0/0
menb 8 (12.1%) 18 (15.2%) 8 (4.9%) 0/0/0
Pregnant (currently)h,d 5 (6.8%) 3 (2.5%) 7 (3.9%) 0/0/0
Volume of self-reported leisure-time physical activity (METh/week)b 23.3 (13.5) 24.7 (14.5) 25.9 (14.2) 3/5/7

*p-value <0.05

**p-value <0.01

p-value <0.001

aChi-square

bOneway ANOVA F-value

c Data available for participants from Finnish Medical Birth Register (FMBR), participants born 1987–1989

d Fisher’s exact test

eSource cohort: FMBR, Finnish Medical Birth Register, participants born 1987–1989; NFBC, Northern Finland Birth Cohort, participants born 1985–1986

fDefinition based on pediatrician’s diagnoses (for NFBC), and the receipt of supplementary oxygen at 28 days of age (for FMBR) [24].

gBMI, body mass index

hOf women only