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. Author manuscript; available in PMC: 2019 Apr 20.
Published in final edited form as: ACS Chem Biol. 2018 Feb 20;13(4):933–941. doi: 10.1021/acschembio.7b01083

Figure 2.

Figure 2.

Assay development. a) Plate-to-plate reproducibility of optimized, single-point readout, 384-well plate format miniaturized assay. A Zʹ score of 0.5 or greater was achieved per plate. Inhibitor 4-Br-BnIm was used as a positive control. b) Post-assay analysis of aggregates by SDS-PAGE reveals dose-responsive rescue of Grp94 from co-aggregation with OLF. S, W, P as in Figure 1.