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. Author manuscript; available in PMC: 2019 Apr 20.
Published in final edited form as: ACS Chem Biol. 2018 Feb 20;13(4):933–941. doi: 10.1021/acschembio.7b01083

Figure 4.

Figure 4.

Dose-responsive rescue of Grp94 from co-aggregation with OLF. a-b) Representative post-assay SDS-PAGE analysis of hit compound (2, a) and negative control (15, b), with control conditions given at the left of each gel. S = supernatant; W = wash; P = pellet/aggregate. c) Densitometric analysis of post-dose-response aggregation assay bands on SDS-PAGE reveals that compounds identified as hits increase the percentage of soluble Grp94 by inhibiting chaperone activity. Data reflect at least 2 experiments and 2 gels per experiment. Error bars indicate standard deviation. Raw data appear in Supplementary Figures S4 and S5.