Table 2. Definitions of behavioral metrics.

#	Measure	Description	Quantification	Direction indicating impairment
Elevated Plus Maze metrics (EPM_)
1	Commitment	Full entrances to the open arms ${(\mathrm{E}\mathrm{n}\mathrm{t}\mathrm{r}}_{\mathrm{O}\mathrm{f}\mathrm{u}\mathrm{l}\mathrm{l}})$ relative to sum of full entrances and jittery entrances to the open arms (${\mathrm{}\mathrm{E}\mathrm{n}\mathrm{t}\mathrm{r}}_{\mathrm{O}\mathrm{j}\mathrm{i}\mathrm{t}\mathrm{t}\mathrm{e}\mathrm{r}}$)	${\displaystyle \frac{\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{O}\mathrm{f}\mathrm{u}\mathrm{l}\mathrm{l}}}{\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{O}\mathrm{f}\mathrm{u}\mathrm{l}\mathrm{l}}+\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{O}\mathrm{j}\mathrm{i}\mathrm{t}\mathrm{t}\mathrm{e}\mathrm{r}}}}$	experimental < controls
2	Distance	Distance traveled (cm) during the ten minutes in the Elevated Plus Maze	${\displaystyle \mathrm{E}\mathrm{P}{\mathrm{M}}_{\mathrm{d}\mathrm{i}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{e}}}$	experimental < controls
3	Exploration Entrances	Entrances into the crossroads central area	${\mathrm{E}\mathrm{n}\mathrm{t}\mathrm{r}}_{\mathrm{c}\mathrm{e}\mathrm{n}\mathrm{t}\mathrm{r}\mathrm{a}\mathrm{l}}$	experimental < controls
4	Exploration Time	Time in the crossroads central area	${\mathrm{T}\mathrm{i}\mathrm{m}\mathrm{e}}_{\mathrm{c}\mathrm{e}\mathrm{n}\mathrm{t}\mathrm{r}\mathrm{a}\mathrm{l}}$	experimental < controls
5	Open-Arm Preference	Time in the open arms (${\displaystyle \mathrm{T}\mathrm{i}\mathrm{m}{\mathrm{e}}_{\mathrm{o}\mathrm{p}\mathrm{e}\mathrm{n}}}$) relative to total time in closed ${\displaystyle \left(\mathrm{T}\mathrm{i}\mathrm{m}{\mathrm{e}}_{\mathrm{c}\mathrm{l}\mathrm{o}\mathrm{s}\mathrm{e}\mathrm{d}}\right)}$and open arms	$\frac{{\mathrm{T}\mathrm{i}\mathrm{m}\mathrm{e}}_{\mathrm{o}\mathrm{p}\mathrm{e}\mathrm{n}}}{{\mathrm{T}\mathrm{i}\mathrm{m}\mathrm{e}}_{\mathrm{c}\mathrm{l}\mathrm{o}\mathrm{s}\mathrm{e}\mathrm{d}}+{\mathrm{T}\mathrm{i}\mathrm{m}\mathrm{e}}_{\mathrm{o}\mathrm{p}\mathrm{e}\mathrm{n}}}$	experimental < controls
Grooming metrics (GR_)
6	Grooming Ratio	Difference betweenaverage grooming bout length in CNO ${(\mathrm{A}\mathrm{V}\mathrm{G}}_{\mathrm{C}\mathrm{N}\mathrm{O}})$ and SALINE condition $\left({\mathrm{A}\mathrm{V}\mathrm{G}}_{\mathrm{s}\mathrm{a}\mathrm{l}\mathrm{i}\mathrm{n}\mathrm{e}}\right)$ relative to SALINE condition	${\displaystyle \frac{\mathrm{A}\mathrm{V}{\mathrm{G}}_{\mathrm{s}\mathrm{a}\mathrm{l}\mathrm{i}\mathrm{n}\mathrm{e}}-\mathrm{A}\mathrm{V}{\mathrm{G}}_{\mathrm{C}\mathrm{N}\mathrm{O}}}{\mathrm{A}\mathrm{V}{\mathrm{G}}_{\mathrm{s}\mathrm{a}\mathrm{l}\mathrm{i}\mathrm{n}\mathrm{e}}}}$	experimental > controls
Social Chamber metrics (SC_)
7	Baseline Distance	Distance traveled (m) during baseline phase (10 min free exploration of the empty social chamber apparatus)	${\displaystyle \mathrm{B}{\mathrm{S}}_{\mathrm{d}\mathrm{i}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{e}}}$	experimental < controls
8	Novelty-Seeking	Difference between summed entrances to mouse ${\displaystyle \left(\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{M}}\right)}$ and object ${\displaystyle \left(\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{O}}\right)}$ chambers in test ${\displaystyle \left({}_{\mathrm{t}\mathrm{e}\mathrm{s}\mathrm{t}}\right)}$ and baseline ${\displaystyle \left({}_{\mathrm{b}\mathrm{s}}\right)}$ sessions, relative to baseline session	${\displaystyle \frac{\left(\left(\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{M}\mathrm{b}\mathrm{s}}+\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{O}\mathrm{b}\mathrm{s}}\right)-\left(\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{M}\mathrm{t}\mathrm{e}\mathrm{s}\mathrm{t}}+\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{O}\mathrm{t}\mathrm{e}\mathrm{s}\mathrm{t}}\right)\right)}{\left(\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{M}\mathrm{b}\mathrm{s}}+\mathrm{E}\mathrm{n}\mathrm{t}{\mathrm{r}}_{\mathrm{O}\mathrm{b}\mathrm{s}}\right)}}$	experimental < controls
9	Social Preference	Time spent interacting with the novel mouse (${\displaystyle \mathrm{T}\mathrm{i}\mathrm{m}{\mathrm{e}}_{\mathrm{N}\mathrm{e}\mathrm{a}\mathrm{r}\mathrm{M}}}$) relative to total time interacting with either the novel mouse or novel object (${\displaystyle \mathrm{T}\mathrm{i}\mathrm{m}{\mathrm{e}}_{\mathrm{N}\mathrm{e}\mathrm{a}\mathrm{r}\mathrm{O}}}$)	${\displaystyle \frac{\mathrm{T}\mathrm{i}\mathrm{m}{\mathrm{e}}_{\mathrm{N}\mathrm{e}\mathrm{a}\mathrm{r}\mathrm{M}}}{\mathrm{T}\mathrm{i}\mathrm{m}{\mathrm{e}}_{\mathrm{N}\mathrm{e}\mathrm{a}\mathrm{r}\mathrm{M}}+\mathrm{T}\mathrm{i}\mathrm{m}{\mathrm{e}}_{\mathrm{N}\mathrm{e}\mathrm{a}\mathrm{r}\mathrm{O}}}}$	experimental < controls
10	Test Distance	Distance traveled (m) during test phase (10 min exploration of the social chamber apparatus with the novel mouse and object present)	${\displaystyle \mathrm{T}\mathrm{e}\mathrm{s}{\mathrm{t}}_{\mathrm{d}\mathrm{i}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{e}}}$	experimental < controls
Y-maze metrics (YM_)
11	Final Learning	Mean of the percent correct trials in acquisition sessions 3 ${\displaystyle \left(\mathrm{A}\mathrm{C}{\mathrm{Q}}_{\mathrm{S}3}\right)}$ and 4 ${\displaystyle \left(\mathrm{A}\mathrm{C}{\mathrm{Q}}_{\mathrm{S}4}\right)}$	${\displaystyle \frac{\mathrm{A}\mathrm{C}{\mathrm{Q}}_{\mathrm{S}3}+\mathrm{A}\mathrm{C}{\mathrm{Q}}_{\mathrm{S}4}}{2}}$	experimental < controls
12	Initial Learning	Percent correct trials in acquisition session 1 ${\displaystyle \left(\mathrm{A}\mathrm{C}{\mathrm{Q}}_{\mathrm{S}1}\right)}$	${\displaystyle \left(\mathrm{A}\mathrm{C}{\mathrm{Q}}_{\mathrm{S}1}\right)}$	experimental < controls
13	Multisession Learning	Slope of the linear regression of acquisition sessions 1 (ACQS1), 2 (ACQS2), and 3 (ACQS3)	linear regression slope of (ACQS1; ACQS2; ACQS3)	experimental < controls
14	Distance	Combined distance swum (m) in the three habituation trials (HAB1, HAB2 and HAB3) (60 s each) of free swimming in the empty Y-maze apparatus	${\displaystyle \mathrm{H}\mathrm{A}\mathrm{B}{1}_{\mathrm{d}\mathrm{i}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{e}}}$+ ${\displaystyle \mathrm{H}\mathrm{A}\mathrm{B}{2}_{\mathrm{d}\mathrm{i}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{e}}}$+ ${\displaystyle \mathrm{H}\mathrm{A}\mathrm{B}{3}_{\mathrm{d}\mathrm{i}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{e}}}$	experimental < controls
15	Final Reversal 1	Mean of the percent correct trials in reversal day 1 sessions 3 (${\displaystyle \mathrm{R}\mathrm{D}{1}_{\mathrm{S}3}}$) and 4 ${\displaystyle \mathrm{R}\mathrm{D}{1}_{\mathrm{S}4}}$	${\displaystyle \frac{\mathrm{R}\mathrm{D}{1}_{S3}+\mathrm{R}\mathrm{D}{1}_{\mathrm{S}4}}{2}}$	experimental < controls
16	Initial Reversal 1	Percent correct trials in reversal day 1 session 1 (RD1S1)	RD1S1	experimental < controls
17	Multisession Reversal 1	Slope of the linear regression of reversal day 1 sessions 1 (RD1S1), 2 (RD1S2) and 3 (RD1S3)	linear regression slope of (RD1S1; RD1S2; RD1S3)	experimental < controls
18	Final Reversal 2	Mean of the percent correct trials in reversal day 2 sessions1 (RD2S1), 2 (RD2S2), 3 (RD2S3) and 4 (RD2S4)	${\displaystyle \frac{\mathrm{R}\mathrm{D}{2}_{S1}+\mathrm{R}\mathrm{D}{2}_{\mathrm{S}2}+\mathrm{R}\mathrm{D}{2}_{\mathrm{S}3}+\mathrm{R}\mathrm{D}{2}_{S4}}{4}}$	experimental < controls
19	Initial Reversal 2	Percent correct trials in reversal day 2 session 1	RD2S1	experimental < controls