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. 2018 Sep 20;7:e37275. doi: 10.7554/eLife.37275

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© 2018, Gmaz et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 3. — (A) Example of a cue-modulated NAc unit that showed an increase in firing following the cue, and exhibited identity coding. Top: raster plot showing the spiking activity across all trials aligned to cue-onset. Spikes across trials are colour-coded according to cue type (red: reward-available light; green: reward-unavailable light; navy blue: reward-available sound; light blue: reward-unavailable sound). Green and magenta bars indicate trial termination when a rat initiated the next trial or made a nosepoke, respectively. White space halfway up the raster plot indicates switching from one block to the next. Dashed line indicates cue-onset. Bottom: PETHs showing the average smoothed firing rate for the unit for trials during light (red) and sound (blue) blocks, aligned to cue-onset. Lightly shaded area indicates standard error of the mean. Note this unit showed a larger increase in firing to sound cues. (B) An example of a unit that was responsive to cue identity as in A, but for a unit that showed a decrease in firing to the cue. Note the sustained higher firing rate during the light block. (C-D) Cue-modulated units that exhibited location coding. Each colour in the PETHs represents average firing response for a different cue location. (C) The firing rate of this unit only changed on arm 3 of the task. (D) Firing rate decreased for this unit on all arms but arm 4. (E-F) Cue-modulated units that exhibited outcome coding, with the PETHs comparing reward-available (red) and reward-unavailable (green) trials. (E) This unit showed a slightly higher response during presentation of reward-available cues. (F) This unit showed a dip in firing when presented with reward-available cues. (G-H) Examples of cue-modulated units that encoded multiple cue features. (G) This unit showed both identity and outcome coding. (H) An example of a unit that coded for both identity and location.

Figure 3—figure supplement 1. — (A) Example of a cue-modulated NAc unit that showed an increase in firing following the cue, and exhibited identity coding. Top: raster plot showing the spiking activity across all trials aligned to cue-onset. Spikes across trials are colour-coded according to cue type (red: reward-available light; green: reward-unavailable light; navy blue: reward-available sound; light blue: reward-unavailable sound). Green and magenta bars indicate trial termination when a rat initiated the next trial or made a nosepoke, respectively. White space halfway up the raster plot indicates switching from one block to the next. Dashed line indicates cue-onset. Bottom: PETHs showing the average smoothed firing rate for the unit for trials during light (red) and sound (blue) blocks, aligned to cue-onset. Lightly shaded area indicates standard error of the mean. Note this unit showed a larger increase in firing to sound cues. (B) An example of a unit that was responsive to cue identity as in A, but for a unit that showed a decrease in firing to the cue. Note the sustained higher firing rate during the light block. (C-D) Cue-modulated units that exhibited location coding. Each colour in the PETHs represents average firing response for a different cue location. (C) The firing rate of this unit only changed on arm 3 of the task. (D) Firing rate decreased for this unit on all arms but arm 4. (E-F) Cue-modulated units that exhibited outcome coding, with the PETHs comparing reward-available (red) and reward-unavailable (green) trials. (E) This unit showed a slightly higher response during presentation of reward-available cues. (F) This unit showed a dip in firing when presented with reward-available cues. (G-H) Examples of cue-modulated units that encoded multiple cue features. (G) This unit showed both identity and outcome coding. (H) An example of a unit that coded for both identity and location.