Table 2. Relative binding affinities of progestogens to steroid receptors and serum binding proteins modified from [1, 13].
| PR | AR | ER | GR | MR | SHBG | CBG | Albumin Bound | Free | |
|---|---|---|---|---|---|---|---|---|---|
| Progesterone | 50 | 0 | 0 | 10 | 0 | 36 | 79.3 | 2.4 | |
| Dydrogesterone | 75 | 0 | – | – | – | – | – | ||
| Chlormadinone acetate | 67 | 5 | 0 | 8 | 0 | 0 | 0 | ||
| Cyproterone acetate | 90 | 6 | 0 | 6 | 8 | 0 | 0 | ||
| Medroxyprogesterone acetate | 115 | 5 | 0 | 29 | 160 | 0 | 0 | ||
| Megestrol acetate | 65 | 5 | 0 | 30 | 0 | 0 | 0 | ||
| Nomegestrol | 125 | 6 | 0 | 6 | 0 | 0 | 0 | ||
| Promegestone (R5020) | 100 | 0 | 0 | 5 | 53 | 0 | 0 | ||
| Drospirenone | 35 | 65 | 0 | 6 | 230 | 0 | 0 | ||
| Norethisterone | 75 | 15 | 0 | 0 | 0 | 16 | 0 | 60.8 | 3.7 |
| Levonorgestrel | 150 | 45 | 0 | 1 | 75 | 50 | 0 | 50 | 2.5 |
| Norgestimate | 15 | 0 | 0 | 1 | 0 | 0 | 0 | ||
| Desogestrel (Etonogestrel) | 150 | 20 | 0 | 14 | 0 | 15 | 0 | 65.5 | 2.5 |
| Gestodene | 90 | 85 | 0 | 27 | 290 | 40 | 0 | 24.1 | 0.6 |
| Dienogest | 5 | 10 | 0 | 1 | 0 | 0 | 0 |
PR = progesterone receptor (promegestone = 100 %), AR = androgen receptor (metribolone = 100 %), ER = estrogen receptor (estradiol-17β = 100 %), GR = glucocorticoid receptor (dexamethason = 100 %), MR = mineralocorticoid receptor (aldosterone = 100 %), SHBG = sex hormone binding globulin (dihydrotestosterone = 100 %), CBG = corticosteroid-binding globulin (cortisol = 100 %).