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. 2018 Oct 19;78(10):949–971. doi: 10.1055/a-0713-1218
No. Recommendation GoR LoE Sources
3.4 An increased risk of developing endometrial cancer was observed following the long-term administration of continuous combined hormone therapy > 6 years or > 10 years. ST 3 9 ,  10
3.5 The administration of progesterone or dydrogesterone in the context of continuous combined hormone therapy may increase the risk of developing endometrial cancer. ST 3 13