Table 3.
Femoral microarchitecture assessed by μCT of 1 and 4 month old Lyz2Cre/WT;Nfatc2Δ/Δ male mice (Nfatc2Δ/Δ) and sex-matched littermate Nfatc2loxP/loxP controls.
| 1 Month | 4 Months | |||
|---|---|---|---|---|
| Control n = 10 |
Nfatc2Δ/Δ n = 7 |
Control n = 8 |
Nfatc2Δ/Δ n = 9 |
|
| Distal Femur Trabecular Bone | ||||
| Bone Volume/Total Volume (%) | 7.2 ± 2.5 | 8.6 ± 2.2 | 7.8 ± 3.0 | 6.8 ± 3.2 |
| Trabecular Separation (μm) | 226 ± 40 | 216 ± 21 | 257 ± 13 | 249 ± 23 |
| Trabecular Number (1/mm) | 4.6 ± 0.7 | 4.7 ± 0.5 | 3.9 ± 0.2 | 4.0 ± 0.4 |
| Trabecular Thickness (μm) | 28 ± 3 | 29 ± 2 | 38 ± 9 | 34 ± 6 |
| Connectivity Density (1/mm3) | 330 ± 190 | 426 ± 162 | 140 ± 45 | 135 ± 56 |
| Structure Model Index | 2.6 ± 0.3 | 2.4 ± 0.2 | 2.1 ± 0.4 | 2.3 ± 0.5 |
| Density of Material (mg HA/cm3) | 946 ± 27 | 942 ± 28 | 1012 ± 14 | 1004 ± 20 |
| Femoral Midshaft Cortical Bone | ||||
| Bone Volume/Total Volume (%) | 82.6 ± 4.2 | 82.6 ± 2.5 | 89.6 ± 0.6 | 89.4 ± 0.5 |
| Porosity (%) | 17.4 ± 4.2 | 17.4 ± 2.5 | 10.4 ± 0.6 | 10.6 ± 0.5 |
| Cortical Thickness (μm) | 95 ± 17 | 94 ± 7 | 171 ± 8 | 170 ± 9 |
| Total Area (mm2) | 1.6 ± 0.1 | 1.6 ± 0.1 | 2.3 ± 0.2 | 2.1 ± 0.2 |
| Bone Area (mm2) | 0.5 ± 0.1 | 0.5 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 |
| Periosteal Perimeter (mm) | 4.4 ± 0.2 | 4.4 ± 0.1 | 5.3 ± 0.3 | 5.2 ± 0.2 |
| Endocortical Perimeter (mm) | 3.7 ± 0.1 | 0.6 ± 0.1 | 4.0 ± 0.2 | 3.9 ± 0.2 |
| Density of Material (mg HA/cm3) | 1049 ± 19 | 1051 ± 14 | 1235 ± 25 | 1224 ± 22 |
μCT was performed on distal femurs for trabecular bone and midshaft for cortical bone. Values are means ± SD.