Table 2.
Correlation and prognostic values of the 48 genes
| Analysis | Correlation: 7 data sets | Survival: logrank high vs low, tertiles | |||||
|---|---|---|---|---|---|---|---|
| Gene | Mean PCC | Stderr PCC | Mean log10(PV) | TCGA | GSE21034 | GSE16560 | GSE25136 |
| APOBEC3B | 0.4856 | 0.0656 | 10.0992 | 1.71E-03 | 1.35E-01 | 2.04E-01 | 2.11E-02 |
| ASF1B | 0.8587 | 0.0325 | 42.3520 | 3.34E-04 | 1.25E-02 | na | 4.91E-01 |
| AURKB | 0.6929 | 0.0714 | 21.6256 | 5.58E-03 | 8.57E-03 | na | 3.59E-01 |
| BIRC5 | 0.8350 | 0.0360 | 43.6592 | 3.33E-04 | 1.10E-03 | 7.25E-07 | 7.92E-02 |
| BUB1B | 0.8192 | 0.0593 | 47.0013 | 7.69E-04 | 1.76E-03 | 2.42E-02 | 1.54E-01 |
| CDC20 | 0.7861 | 0.0787 | 37.6874 | 2.95E-05 | 4.01E-04 | 4.95E-02 | 1.18E-01 |
| CDCA5 | 0.9218 | 0.0053 | 60.1906 | 3.67E-06 | 3.35E-03 | na | na |
| CDCA8 | 0.8701 | 0.0486 | 50.5426 | 1.50E-04 | 6.42E-03 | na | 4.30E-01 |
| CDKN3 | 0.8370 | 0.0317 | 43.7493 | 4.53E-03 | 5.89E-05 | 4.39E-04 | 6.98E-02 |
| CEP55 | 0.8610 | 0.0418 | 48.5437 | 2.40E-03 | 2.92E-03 | na | 1.85E-01 |
| DEPDC1B | 0.8575 | 0.0280 | 49.0341 | 7.68E-03 | 5.62E-04 | na | na |
| DIP2B | 0.2916 | 0.0909 | 4.6882 | 4.87E-01 | 4.23E-01 | na | na |
| DLGAP5 | 0.9002 | 0.0219 | 56.1288 | 4.81E-04 | 1.80E-04 | na | 2.65E-01 |
| DNMT3B | 0.6054 | 0.0372 | 15.7632 | 1.59E-03 | 9.30E-02 | na | 3.55E-01 |
| DTL | 0.8058 | 0.0435 | 42.5223 | 2.13E-03 | 3.76E-04 | na | 3.02E-01 |
| EXO1 | 0.8281 | 0.0500 | 46.2383 | 2.23E-04 | 7.67E-03 | na | 2.84E-01 |
| EZH2 | 0.7299 | 0.0609 | 28.9437 | 3.91E-04 | 8.41E-02 | 1.10E-02 | 7.81E-02 |
| FOXM1 | 0.8335 | 0.0627 | 48.5116 | 1.13E-03 | 4.23E-04 | 3.88E-03 | 2.13E-01 |
| GTSE1 | 0.6820 | 0.1217 | 26.8985 | 8.75E-05 | 1.08E-03 | 1.76E-01 | 1.25E-01 |
| HJURP | 0.7048 | 0.0814 | 20.2463 | 2.79E-04 | 9.97E-02 | na | 4.75E-01 |
| IQGAP3 | 0.6107 | 0.1535 | 22.2494 | 2.42E-04 | 4.65E-04 | na | na |
| KDM2B | 0.4024 | 0.0749 | 9.5927 | 3.72E-01 | 2.97E-02 | na | na |
| KDM5B | 0.2053 | 0.1030 | 3.1869 | 1.40E-01 | 3.65E-01 | na | 9.14E-03 |
| KIAA0101 | 0.7584 | 0.0641 | 32.3947 | 1.38E-03 | 4.84E-03 | 3.58E-03 | 7.48E-04 |
| L2HGDH | 0.2832 | 0.0595 | 3.3340 | 1.91E-01 | 1.80E-01 | na | 6.02E-02 |
| LMNB1 | 0.7537 | 0.0679 | 35.3260 | 8.35E-04 | 8.12E-03 | 2.35E-03 | 2.89E-01 |
| LRPPRC | 0.1656 | 0.0661 | 2.0329 | 8.44E-03 | 2.58E-01 | 4.59E-02 | 7.25E-03 |
| MELK | 0.8342 | 0.0617 | 49.5800 | 3.21E-03 | 5.06E-05 | 3.22E-02 | 2.03E-04 |
| MYBL2 | 0.7365 | 0.0773 | 32.5805 | 9.75E-06 | 2.61E-04 | 4.22E-02 | 1.45E-01 |
| NAA15 | 0.2681 | 0.0687 | 3.6134 | 4.18E-01 | na | na | 7.01E-02 |
| NCAPG | 0.8956 | 0.0387 | 59.2214 | 1.68E-04 | 8.05E-04 | na | 1.48E-01 |
| PBK | 0.8279 | 0.0386 | 42.1333 | 4.35E-05 | 5.63E-05 | na | 1.57E-02 |
| PLK1 | 0.7966 | 0.0774 | 42.1368 | 2.77E-06 | 3.71E-04 | 2.14E-01 | 1.84E-01 |
| PTTG1 | 0.8281 | 0.0344 | 42.8207 | 1.68E-03 | 2.82E-03 | 9.37E-05 | 2.78E-02 |
| RAD51 | 0.6930 | 0.0941 | 27.9681 | 1.44E-02 | 2.89E-02 | 3.45E-01 | 4.06E-01 |
| RAD54L | 0.7185 | 0.0951 | 29.8411 | 5.19E-05 | 1.06E-02 | 1.01E-01 | 4.39E-02 |
| RRM2 | 0.8386 | 0.0362 | 44.2879 | 1.54E-04 | 7.28E-05 | 8.74E-04 | 9.17E-05 |
| SPAG5 | 0.8269 | 0.0643 | 47.5110 | 2.63E-07 | 1.02E-03 | 1.57E-03 | 2.29E-01 |
| TET3 | 0.3346 | 0.0705 | 3.8902 | 1.85E-01 | 3.58E-01 | na | 5.47E-02 |
| TK1 | 0.8103 | 0.0325 | 37.8871 | 1.07E-04 | 3.49E-02 | 1.32E-03 | 4.63E-01 |
| TMEM97 | 0.4398 | 0.0693 | 9.7922 | 8.43E-02 | 8.45E-02 | 4.25E-02 | 3.90E-01 |
| TOP2A | 0.8044 | 0.0493 | 37.9232 | 1.20E-04 | 9.33E-04 | 3.32E-04 | 1.32E-02 |
| TPX2 | 0.8554 | 0.0752 | 56.1147 | 2.00E-06 | 3.63E-04 | 2.05E-01 | 3.11E-01 |
| TRIP13 | 0.6271 | 0.1025 | 25.6237 | 1.23E-03 | 3.19E-02 | 2.17E-05 | 2.76E-01 |
| TROAP | 0.7652 | 0.0682 | 29.6392 | 2.06E-05 | 2.15E-02 | 7.45E-03 | 4.81E-01 |
| TTK | 0.6963 | 0.0593 | 29.1810 | 5.31E-03 | 1.58E-03 | 3.78E-01 | 2.38E-01 |
| UBE2C | 0.8870 | 0.0318 | 59.0475 | 5.03E-06 | 6.06E-04 | 3.86E-03 | 1.31E-01 |
| UHRF1 | 0.8612 | 0.0150 | 43.4272 | 4.80E-05 | 2.91E-03 | na | na |
Pearson correlation coefficients (PCC) between individual gene expression and the mean expression of the 48 gene set were calculated in seven data sets (TCGA, GSE21034, GSE16560, GSE25136, GSE35988, SU2C, FHCC). Average PCC and standard errors are listed, along with the average –log10(p-value) of the correlations. Survival columns contain logrank p-values for Kaplan–Meier analyses for individual genes, calculated by splitting each data set into tertiles based on expression, and comparing high versus low tertiles. Note that in GSE25136 this yields lower p-values due to the small size of groups (n = 79)