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. 2018 Oct 19;8:15483. doi: 10.1038/s41598-018-33768-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vessel damage caused by transcardial infusion of red PKH26 platelets (a,d) isolated from transgenic Alzheimer mice. Vessels were stained with Collagen IV (Alexa 647, (b) or Lectin-649 (e,h). Merged pictures showing red penetrating platelets in vessels are given in Figure (c,f). Staining for anti-mouse IgG (Alexa-488; g) shows vessel damage. Note several holes (arrows in b,e,h) in the vessel, where the platelet penetrates the vessel, indicating vessel damage. Scale bar in a = 7 µm (a–i).