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. 2018 Oct 19;8(11):98. doi: 10.1038/s41408-018-0134-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b. SAMHD1 is predominantly expressed in the nucleus of AML blasts. A representative AML case with high SAMHD1 expression (>75%) (a). Morphology of blasts is shown by routine hematoxylin-eosin (H&E) stain of bone marrow section (b) and by May-Grünwald Giemsa (MGG) stain of bone marrow smear (b, inset) (original magnification ×400 for a, b (and ×600 for b, inset). c, d. A representative case of AML with low SAMHD1 expression (<25%) (c). Morphology of blasts is shown by H&E stain of bone marrow section (d) and by MGG stain of bone marrow smear (d, inset) (original magnification ×400 for c, d and ×600 for d, inset). e Examples of double immunostainings (SAMHD1/CD34) in two CD34+ AML cases, one with SAMHD1-/CD34+ blasts (left) and another with SAMHD1+/CD34+ blasts (right). (original magnification ×600; SAMHD1 in dark brown; CD34 in red). f Histogram showing the distribution of SAMHD1 expression level (% of positive blasts) in TMAs of AML patients