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. 2018 Oct 19;8:15472. doi: 10.1038/s41598-018-33932-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tracer-decorated human aqueous outflow pattern. Frontal sections of anterior segments showing tracer distribution in (A) vehicle control, (B) SB77 (50 µM) treated eyes. Tracer distribution was more uniform, intense and widely spread all over the meshwork and also in the inner wall of SC in SB77-treated eyes as compared to vehicle-treated eyes. (C) Measurement of TM thickness in tracer decorated region. A marginal 11.2% increase in TM thickness was observed in SB77-treated eyes as compared to vehicle-treated eyes (SB77-treated eyes: 129.29 ± 14.3 µm, vehicle control eyes: 116.09 ± 16.7 µm; n = 3; p = 0.354; unpaired t-test). TM-Trabecular meshwork; SC-Schlemm’s canal and S-Sclera.