Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 19;8:15472. doi: 10.1038/s41598-018-33932-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of SB77 on mRNA expression of fibrotic markers by quantitative RT-PCR. A significant reduction in mRNA levels of Fibronectin (p = 0.005), COL1A1 (p = 0.015), α-SMA (p = 0.038) and FSP-1(p = 0.019) compared to vehicle control was achieved with SB77 treatment. Y27632 treatment also showed similar fold changes, except for the larger change in COL4A1. β-catenin mRNA levels were reduced significantly in SB77- treated cells as compared to vehicle controls (p = 0.000) but it was not found to be significant when compared with Y27632-treated cells (p = 0.088), whereas COL4A1 was significantly reduced in Y27632 treated cells as compared to vehicle-treated cells (p = 0.001). The fold change in gene expression was calculated by the 2^−ΔΔCt method, with GAPDH as a house-keeping gene. *p < 0.05; **p < 0.001; ***p < 0.0001(n = 3); Treated (SB77 or Y27632) vs vehicle control group, paired Student’s t-test.