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. 2018 Oct 19;8:15472. doi: 10.1038/s41598-018-33932-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of the effect of SB77 on IOP in HOCAS. Rho kinase is reported to mediate smooth muscle contraction by phosphorylating the myosin-light chain (MLC) directly and by decreasing myosin phosphatase activity indirectly, resulting in increased actin fiber formation and high intraocular pressure. SB77, a new Rho kinase inhibitor enhanced outflow facility in human eyes. This could be due to cellular relaxation of the TM mediated through inhibition of Rho kinase. This results in decreased p-MLC, altered cytoskeletal rearrangement and reduced fibrotic markers.