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. 2018 Oct 19;9:4357. doi: 10.1038/s41467-018-06530-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Effect of NK-3R stimulation on ERP and AF inducibility in atria of human and rabbit. a Unipolar electrograms recorded from the left atrium of a Langendorff-perfused rabbit heart before (Control) and after application of 20 nM of Senktide (left). Bar graph showing average values for AERP in Control, in the presence of 20 nM Senktide, and after wash-out (right, N = 7, one-way RM ANOVA). b Unipolar electrograms recorded from human LAA before (Control) and after application of 100 nM of Senktide (left). Bar graph showing average values for AERP in Control and in the presence of 50–200 nmol/L Senktide (right, N = 5, paired t-test, p = 0.06). c Unipolar electrograms recorded from the left atrium of a rabbit Langendorff-perfused heart following a burst pacing protocol in the absence (Control, left) and in the presence of 20 nM of the NK-3R agonist Senktide (right), at baseline (0 cm H₂O, upper tracings) and during atrial dilatation (20 cm H₂O, lower tracings). d, e Bar graph showing average values for total duration of arrhythmia episodes d and AF incidence e in Control, after application of 20 nM Senktide, and after wash-out (N = 7, two-way RM ANOVA). All values shown are mean ± SEM. *P < 0.05. Electrograms: A atrial activation; V ventricular activation; * stimulus