Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 19;8:15508. doi: 10.1038/s41598-018-33975-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Hypothesized model of pathways involved in increased coronavirus shedding and white-nose syndrome (WNS) severity in little brown bats (Myotis lucifugus) co-infected with M. lucifugus coronavirus (Myl-CoV) and Pseudogymnoascus destructans. Diagram summarizes the changes observed by comparing co-infected bats with virus-infected bats. Bats with persistent Myl-CoV infection exhibit relatively low viral shedding. When bats are also infected with P. destructans (shown in yellow arrow) and develop WNS, the level of coronavirus increases. There is a change in the level of some immune genes, such as IL22, RERG and possibly IL10, which may have an effect on immune response and cell proliferation. The increase in coronavirus levels in co-infected bats is possibly due to the bats’ systemic response to WNS reducing innate anti-viral responses.