FIG. 7.

Effects of antagonists to acid-sensing ion channels (ASICs; A-317567: filled triangles) and transient receptor potential of the vanilloid type 1 (TRPV1; JYL-1433 and LJO-328: open circles and squares, respectively) at indicated doses on responses to increased metabolites as presented in previous graphs. Controls (filled diamonds) received only the metabolite increases indicated on the x-axis. For the antagonist applications, each well averaged 108 ± 5 neurons imaged for calcium increases. Statistical analyses used wells as the sample size.