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Summary of the main results of this study. The expression profiles of BAVc and TAVc were highly similar. Additional unique genes were identified in BAVc vs. TAVn compared with TAVc vs. TAVn. Bicuspid aortic valve calcification may be mediated by BMP and Wnt signaling pathway genes. Calcium signaling pathway genes were upregulated specifically in TAVc vs. TAVn. The angiotensin and fibrosis pathways were altered in both BAVc and TAVc compared with TAVn.
