Table 5.
Top up- and downregulated genes in the three pairwise comparisons
| Symbol | Gene Name | Mean FPKM | Mean FPKM | FC | q-value |
|---|---|---|---|---|---|
| BAVc vs. TAVc | BAVc | TAVc | |||
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 65.48 | 40.03 | 1.64 | 0.011 |
| RSPO2 | R-spondin 2 | 4.51 | 2.23 | 2.03 | 0.011 |
| BAVc vs. TAVn | BAVc | TAVn | |||
| MMP13 | matrix metallopeptidase 13 (collagenase 3) | 2.44 | 0.00 | INF | 0.002 |
| KRT14 | keratin 14 | 11.52 | 0.11 | 105.08 | 0.002 |
| IBSP | integrin-binding sialoprotein | 24.45 | 0.25 | 99.67 | 0.002 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 8.12 | 0.28 | 29.48 | 0.002 |
| CCL11 | chemokine (C-C motif) ligand 11 | 5.04 | 0.19 | 26.68 | 0.006 |
| COL10A1 | collagen, type X, alpha 1 | 4.15 | 0.16 | 26.11 | 0.016 |
| STMN2 | stathmin-like 2 | 18.35 | 0.73 | 25.21 | 0.002 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 2.11 | 0.10 | 22.04 | 0.002 |
| ELK2AP | ELK2A, member of ETS oncogene family, pseudogene | 609.28 | 27.79 | 21.92 | 0.002 |
| COL11A1 | collagen, type XI, alpha 1 | 4.10 | 0.21 | 19.25 | 0.002 |
| MYOC | myocilin, trabecular meshwork inducible glucocorticoid response | 10.17 | 96.52 | −9.49 | 0.002 |
| LYPD6 | LY6/PLAUR domain containing 6 | 0.09 | 0.88 | −9.70 | 0.004 |
| TUSC5 | tumor suppressor candidate 5 | 0.20 | 2.03 | −10.18 | 0.002 |
| GPM6A | glycoprotein M6A | 0.37 | 3.79 | −10.38 | 0.002 |
| LCN12 | lipocalin 12 | 0.23 | 2.47 | −10.66 | 0.002 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 0.24 | 2.96 | −12.44 | 0.002 |
| NPY | neuropeptide Y | 0.31 | 5.48 | −17.56 | 0.002 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 6.74 | 124.09 | −18.40 | 0.002 |
| NTS | neurotensin | 0.32 | 6.76 | −21.28 | 0.004 |
| MUM1L1 | melanoma associated antigen (mutated) 1-like 1 | 0.25 | 7.66 | −31.18 | 0.002 |
| TAVc vs. TAVn | TAVc | TAVn | |||
| IBSP | integrin-binding sialoprotein | 37.26 | 0.26 | 145.49 | 0.001 |
| KRT14 | keratin 14 | 4.47 | 0.12 | 38.34 | 0.001 |
| COL10A1 | collagen, type X, alpha 1 | 5.66 | 0.17 | 32.85 | 0.028 |
| COL11A1 | collagen, type XI, alpha 1 | 6.17 | 0.22 | 28.17 | 0.001 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 7.10 | 0.28 | 25.16 | 0.001 |
| IGJ | immunoglobulin J polypeptide, linker protein for immunoglobulin α and μ polypeptides | 112.36 | 4.92 | 22.83 | 0.001 |
| CCL11 | chemokine (C-C motif) ligand 11 | 4.39 | 0.20 | 22.41 | 0.006 |
| STMN2 | stathmin-like 2 | 14.55 | 0.72 | 20.25 | 0.001 |
| MMP12 | matrix metallopeptidase 12 (macrophage elastase) | 8.81 | 0.54 | 16.38 | 0.001 |
| SPP1 | secreted phosphoprotein 1 | 1772.64 | 115.18 | 15.39 | 0.001 |
| MYOC | myocilin, trabecular meshwork inducible glucocorticoid response | 18.66 | 99.26 | −5.32 | 0.001 |
| GPM6A | glycoprotein M6A | 0.72 | 3.88 | −5.39 | 0.001 |
| CNTFR | ciliary neurotrophic factor receptor | 2.30 | 14.11 | −6.14 | 0.001 |
| APOA1 | apolipoprotein A-I | 2.11 | 13.87 | −6.58 | 0.001 |
| AGTR1 | angiotensin II receptor, type 1 | 0.15 | 1.04 | −6.86 | 0.005 |
| CHODL | chondrolectin | 0.27 | 2.00 | −7.36 | 0.001 |
| PNMT | phenylethanolamine N-methyltransferase | 0.28 | 2.84 | −10.20 | 0.001 |
| WIF1 | WNT inhibitory factor 1 | 0.83 | 9.07 | −10.98 | 0.001 |
| NPY | neuropeptide Y | 0.22 | 5.45 | −24.62 | 0.003 |
| MUM1L1 | melanoma associated antigen (mutated) 1-like 1 | 0.30 | 8.45 | −28.33 | 0.001 |
FC, fold change; FPKM, fragments per kilobase of transcript per million mapped reads.